NCT06877273: CIRCuiTS-MS

Improving Cognitive Recovery in Multiple Sclerosis

Active, enrolled NA Last updated 17 April 2026

What this trial tests

NA trial testing CIRCuiTS-MS in Multiple Sclerosis in 24 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

17 July 2025

Primary endpoint
15 September 2026

15 September 2026

Quick facts

Lead sponsor	King's College London
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	24
Start date	17 July 2025
Primary completion	15 September 2026
Estimated completion	15 September 2026
Sites	1 location across United Kingdom

Drugs / interventions tested

• CIRCuiTS-MS

Conditions studied

• Multiple Sclerosis — all drugs for Multiple Sclerosis →

Sponsor

King's College London

Who can join

18 and older, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to find out whether an adapted version of an existing cognitive rehabilitation program, CIRCuiTS (https://www.circuitstherapyinfo.com), can be used to improve everyday thinking skills for people with Multiple Sclerosis (MS). People living with MS have worked with the study's researchers to adapt CIRCuiTS to meet their needs. They shared the thinking challenges they experience and suggested changes to the program's content and how it is delivered. This study will test whether this adapted version can be delivered practically to people with MS in a trial setting and explore its potential benefits. The findings will help plan a larger trial testing how effective CIRCuiTS is in helping people with MS.

Twenty-four people with MS will take part in this pilot trial. Each person will be randomly assigned to start the program either right away or after a 13-week wait. The therapy program involves up to 36 hours of therapist-led and independent sessions over 12 weeks in which the participant builds thinking skills through developing personal strategies for carrying out digital versions of tasks they find challenging. The practicality of delivering the program to people with MS will be judged based on whether problems arise in the trial, such as not being able to recruit enough people or participants not liking it. To explore its potential benefits, the study will check for improvements in progress toward personal goals, thinking abilities, emotional well-being, chronic tiredness, and daily living skills after the therapy.

If delivering CIRCuiTS to people with MS is found to be both practical and acceptable to participants, the findings of this trial will be used to design a larger-scale trial of its effectiveness. Ultimately, the goal of this project is to improve the quality of life of people living with cognitive difficulties related to MS.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.