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NCT06874387: HYPOX-AGE
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
NA trial testing Hypoxia, intermittent in Cognitive Ability, General in 176 participants. Not yet recruiting.
30 September 2026
Quick facts
| Lead sponsor | Ayoub Boulares |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 176 |
| Start date | 1 April 2025 |
| Primary completion | 30 September 2026 |
| Estimated completion | 30 December 2026 |
Drugs / interventions tested
- Hypoxia, intermittent — full drug profile →
- physical exercise
- Sham (No Treatment) hypoxia
Conditions studied
- Cognitive Ability, General — all drugs for Cognitive Ability, General →
- Brain Health — all drugs for Brain Health →
- Cerebral Oxygenation — all drugs for Cerebral Oxygenation →
Sponsor
Ayoub Boulares
Who can join
Adults 50 to 65, any sex, with Cognitive Ability, General or Brain Health. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65 years old). The hypothesis is that (1) each intervention alone (IHT or PA) provides cognitive benefits and (2) combining IHT with PA may yield additive or synergistic effects, particularly when administered simultaneously rather than sequentially. By comparing these distinct interventions, the study aims to determine which approach best preserves or enhances cognitive performance in middle-aged adults. Findings from this research may inform non-pharmacological strategies to promote healthy aging and reduce the risk of age-related cognitive decline.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06874387
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Hypoxia, intermittent
Trials testing the same drug.
- NCT05210088 — PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke · Phase 1, PHASE2 · withdrawn
Other recruiting trials for Cognitive Ability, General
Currently open trials in the same condition.
- NCT06775132 — Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes · recruiting
- NCT06989697 — Cilostazol-Ginkgo for Cognitive Function in Elderly Diabetes · Phase 3 · recruiting
- NCT05814094 — Red Blood Cell Transfusion in ECMO - A Feasibility Trial · NA · recruiting
- NCT06781541 — Physical Activity and Disability Prevention in Postmenopausal Women · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06874387 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ayoub Boulares
- Last refreshed: 13 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06874387.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing