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NCT06874127
Non-Invasive Model for Fibrosis Regression in HBV Patients
trial testing Nucleos(t)ide Analogs (NA) in Chronic Hepatitis B Virus (HBV) Infection in 1,100 participants. Currently enrolling.
1 February 2026
Quick facts
| Lead sponsor | Beijing Friendship Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,100 |
| Start date | 1 February 2024 |
| Primary completion | 1 February 2026 |
| Estimated completion | 1 May 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Nucleos(t)ide Analogs (NA) — full drug profile →
Conditions studied
- Chronic Hepatitis B Virus (HBV) Infection — all drugs for Chronic Hepatitis B Virus (HBV) Infection →
- Liver Fibrosis — all drugs for Liver Fibrosis →
Sponsor
Beijing Friendship Hospital
Who can join
18 and older, any sex, with Chronic Hepatitis B Virus (HBV) Infection or Liver Fibrosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A total of 1000 chronic hepatitis B (CHB) patients with liver biopsy performed at least 1 year after antiviral therapy are retrospectively enrolled. All the patients received NAs treatment. Blood count, liver function test, alpha fetoprotein (AFP), prothrombin time, liver ultrasonography, liver stiffness measurement (LSM), Hepatitis B virus (HBV) DNA and HBV serological markers were collected. HBV-related endpoint events, including cirrhosis decompensations (ascites, esophageal variceal bleeding and hepatic encephalopathy), hepatocellular carcinoma (HCC), liver transplantation and liver-related death were collected. Fibrosis regression prediction model based on dynamic changes in liver stiffness will be developed based on the retrospective cohort. An independent cohort of CHB patients with liver biopsy performed at least 1 year after antiviral therapy will be retrospectively enrolled for model validation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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- PubMed search for NCT06874127
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Related trials
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Other recruiting trials for Chronic Hepatitis B Virus (HBV) Infection
Currently open trials in the same condition.
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Other Beijing Friendship Hospital trials
Trials by the same sponsor.
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- NCT07441850 — Digital Rehabilitation for Gastric Cancer Surgery After Neoadjuvant Therapy · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06874127 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Friendship Hospital
- Last refreshed: 13 March 2025
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