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Pre-malignant States to Hematologic Malignancies in Firefighters
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.
Details
| Lead sponsor | Wake Forest University Health Sciences |
|---|---|
| Status | RECRUITING |
| Enrolment | 300 |
| Start date | 2026-06 |
| Completion | 2027-04 |
Conditions
- Clonal Hematopoiesis of Indeterminate Potential
- Monoclonal Gammopathy
- Non Hodgkin Lymphoma
- Leukemia
- Multiple Myeloma
- Plasma Cell Disorder
Interventions
- Monoclonal Gammopathy
- Complete Blood Count with differential (CBC w/ diff)
- Clonal hematopoiesis (CHIP)
Primary outcomes
- Clonal Hematopoiesis (CHIP) — From enrollment to availability of lab results, approximately 6 months
The presence of positive somatic mutation will be determined for each enrolled participant as a binary variable indicating if the participant is harboring clonal hematopoiesis.
Countries
United States