NCT06868004

Holistic Nursing Benefits Cognitive and Psychiatric Symptoms in Alzheimer's Patients

Completed NA Last updated 10 March 2025

What this trial tests

NA trial testing Holistic Nursing in Alzheimer Disease in 105 participants. Completed in 31 January 2024.

Timeline

1 January 2023

Primary endpoint
31 January 2024

31 January 2024

Quick facts

Lead sponsor	The First People's Hospital of Jingzhou
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	105
Start date	1 January 2023
Primary completion	31 January 2024
Estimated completion	31 January 2024
Sites	1 location across China

Drugs / interventions tested

• Holistic Nursing

Conditions studied

• Alzheimer Disease — all drugs for Alzheimer Disease →

Sponsor

The First People's Hospital of Jingzhou

Who can join

Adults 60 to 80, any sex, with Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This clinical study aims to evaluate the effects of a holistic nursing (HN) intervention on cognitive function, psychological well-being, and overall health outcomes in patients with Alzheimer's disease (AD). AD is a progressive neurodegenerative disorder characterized by cognitive decline and behavioral changes, significantly impacting patients' quality of life and increasing the burden on caregivers. Conventional treatment primarily involves pharmacological interventions, but non-pharmacological approaches, such as specialized nursing care, have shown potential in improving patient outcomes.

This study prospectively enrolled 105 AD patients admitted to our hospital between January 2023 and January 2024. Patients were divided into two groups based on admission periods: the control group (n=58) received standard care, while the observation group (n=47) received HN in addition to standard care. The HN intervention was implemented based on established guidelines for older adults with cognitive impairment and consisted of five key components: psychological support, cognitive stimulation, memory enhancement, self-care training, and environmental optimization.

The study assessed cognitive function, psychiatric symptoms, anxiety, and depression levels before and after the intervention using validated scales, including the Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog), Montreal Cognitive Assessment (MoCA), and Self-rating Anxiety/Depression Scales (SAS/SDS). Additionally, blood biomarkers related to neurological function, such as dopamine, acetylcholine, serotonin, γ-aminobutyric acid, S100β, homocysteine, and interleukin-1β, were measured.

Patient compliance, safety outcomes, and family satisfaction with the nursing intervention were also evaluated. The findings of this study may provide evidence supporting the integration of HN as a complementary approach in AD management, potentially improving cognitive function, reducing psychiatric symptoms, and enhancing overall patient well-being.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Positive Impact of Holistic Nursing on Cognitive Impairment and Psychiatric Symptoms in Patients With Alzheimer's Disease.
   Yu J, Zhu L, Song Y, Shi B, et al · · 2025 · cited 1× · PMID 40355993 · DOI 10.62641/aep.v53i3.1948