NCT06866925 (TOTORO) is a NA clinical trial of Transcranial stimulation in Down Syndrome, sponsored by Hôpital le Vinatier.

Who is sponsoring NCT06866925?

NCT06866925 is sponsored by Hôpital le Vinatier.

What drugs are being tested in NCT06866925?

Interventions in NCT06866925: Transcranial stimulation.

What condition does NCT06866925 study?

NCT06866925 studies Down Syndrome.

Is NCT06866925 still recruiting?

NCT06866925 is currently not yet recruiting. Last updated 30 July 2025.

Last reviewed 2025-07-30 · How we verify

NCT06866925: TOTORO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

tDCS for Catatonic Depression in Down Syndrome: A Pilot Study

Not yet recruiting NA Last updated 30 July 2025

What this trial tests

NA trial testing Transcranial stimulation in Down Syndrome in 62 participants. Not yet recruiting.

Timeline

12 September 2025

Primary endpoint
1 August 2027

30 September 2027

Quick facts

Lead sponsor	Hôpital le Vinatier
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	62
Start date	12 September 2025
Primary completion	1 August 2027
Estimated completion	30 September 2027

Drugs / interventions tested

Transcranial stimulation

Conditions studied

Down Syndrome — all drugs for Down Syndrome →

Sponsor

Hôpital le Vinatier — full company profile →

Who can join

18 and older, any sex, with Down Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates the efficacy of transcranial direct current stimulation (tDCS) for depression with catatonia in individuals with Down syndrome (DS). 62 patients will be randomized to receive 15 sessions of active or sham tDCS. The primary objective is to measure changes in depressive/catatonic symptoms using the Bush-Francis Catatonia Rating Scale (BFCRS). Secondary objectives include safety, cognitive effects, EEG correlates, and biological markers (cortisol, BDNF, cytokines). The study aims to provide a non-pharmacological therapeutic alternative for this population

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Transcranial stimulation

Trials testing the same drug.

NCT05250713 — Evaluation of Direct Effects of Electric Fields on Brain · NA · completed
NCT04605367 — Mental Practice (MP) Combined With Transcranial Direct Current Stimulation (tDCS) on Motor Learning in the Elderly · NA · unknown

Other recruiting trials for Down Syndrome

Currently open trials in the same condition.

NCT07416201 — Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy · recruiting
NCT07484464 — Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Syndrome · NA · recruiting
NCT07428863 — Effects of Jump Rope on Navicular Drop in Down Syndrome · NA · recruiting
NCT07260136 — Cervical Spine Abnormalities in Down Syndrome · active not recruiting
NCT07248449 — Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises · NA · recruiting

Other Hôpital le Vinatier trials

Trials by the same sponsor.

NCT07428200 — Characterization of the Neural Bases of Mental Imagery in Individuals With Borderline Personality Disorder: An EEG Study · NA · not yet recruiting
NCT07384819 — Duration of Moment in Autism · NA · not yet recruiting
NCT06284382 — Interaction Between Early Trauma and Odor-induced Dopamine Release · NA · not yet recruiting
NCT07119671 — Peer-aid and Hope Box · NA · not yet recruiting
NCT06869915 — Homelessness and Prevalence of Neurodevelopmental Disorders · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06866925 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hôpital le Vinatier
Last refreshed: 30 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06866925.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing