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NCT06864910
Brain Functional Changes Accompany Modulatory Effects of Transcranial Direct Current Stimulation in Cognitive Impairment
trial testing anodal transcranial Direct Current Stimulation in Cognitive Impairment in 40 participants. Completed in 16 December 2022.
16 December 2022
Quick facts
| Lead sponsor | National Institute of Mental Health and Neuro Sciences, India |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 5 August 2019 |
| Primary completion | 16 December 2022 |
| Estimated completion | 16 December 2022 |
| Sites | 2 locations across India |
Drugs / interventions tested
- anodal transcranial Direct Current Stimulation
Conditions studied
- Cognitive Impairment — all drugs for Cognitive Impairment →
Sponsor
National Institute of Mental Health and Neuro Sciences, India
Who can join
55 and older, any sex, with Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study was to examine the brain functional alterations accompanying cognitive modulatory effect of anodal transcranial Direct Current Stimulation (tDCS) in sample patients with early Alzheimer's Disease (AD), registered under Geriatric Clinic and Services at NIMHANS, and who were initiated on tDCS for cognitive enhancement. Further, to explore the potential beneficial effect of tDCS, the investigators offered the intervention to the first 40 consenting patients from the amnestic Mild Cognitive Impairment (aMCI) (n=21) and mild AD (n=19) samples. The changes in functional connectivity/activations associated with diminished cognitive functions were examined using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG), between pre- and post-tDCS intervention. The administration of tDCS followed the standard procedures using a neuroConn DC-Stimulator Plus device (neuroCare Group GmbH, Munich, Germany) with the anode placed at F3 (left DLPFC) and the cathode over the right supraorbital region (Fp2) using 5x7cm electrodes. The anodal tDCS intervention involved daily sessions (between 10-11 a.m.) for 10 consecutive days, wherein a direct current (DC) of 2 mA was administered for 20 minutes (with additional ramp-up and ramp-down phase of 20 seconds each at the beginning and end of the session respectively), adhering to stringent safety measures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer's disease.
Joshi H, Nair G, Roy AA, Havanur S, et al · · 2026 · PMID 41993066 · DOI 10.3389/fnhum.2026.1767772
Verify or expand the search:
- PubMed search for NCT06864910
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06864910 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute of Mental Health and Neuro Sciences, India
- Last refreshed: 7 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06864910.
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