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NCT06863116
Analysis of HIF-1α, MDA, and GPX4 in Peri-Implant Crevicular Fluid
trial in Peri-Implantitis and Peri-implant Mucositis in 45 participants. Completed in 16 July 2024.
15 May 2024
Quick facts
| Lead sponsor | Ege University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 45 |
| Start date | 15 May 2023 |
| Primary completion | 15 May 2024 |
| Estimated completion | 16 July 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Peri-Implantitis and Peri-implant Mucositis — all drugs for Peri-Implantitis and Peri-implant Mucositis →
- Hypoxia — all drugs for Hypoxia →
- Ferroptosis — all drugs for Ferroptosis →
Sponsor
Ege University
Who can join
18 and older, any sex, with Peri-Implantitis and Peri-implant Mucositis or Hypoxia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions that affect the tissues surrounding dental implants. If untreated, these diseases can lead to bone loss and implant failure. This study investigates whether low oxygen levels (hypoxia) in the peri-implant environment influence ferroptosis, a type of cell death associated with oxidative stress. The research focuses on three key biomarkers: hypoxia-inducible factor-1 alpha (HIF-1α), glutathione peroxidase-4 (GPX-4), and malondialdehyde (MDA). A total of 45 participants with 62 dental implants were included in the study. They were divided into three groups: peri-implant health, peri-implant mucositis, and peri-implantitis. Peri-implant crevicular fluid (PICF) samples were collected, and the levels of HIF-1α, GPX-4, and MDA were measured using laboratory tests. The study aims to determine whether hypoxia affects ferroptosis-related pathways by altering GPX-4 and MDA levels. Understanding these mechanisms could provide new insights into peri-implant disease progression and help develop improved treatment strategies.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06863116
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Related trials
Other recruiting trials for Peri-Implantitis and Peri-implant Mucositis
Currently open trials in the same condition.
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- NCT06740123 — Evaluation of Hydrogel Application in the Treatment of Periodontitis and Peri-implantitis · NA · active not recruiting
Other Ege University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06863116 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ege University
- Last refreshed: 7 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06863116.
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