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NCT06861803
Laboratory and Ultrasound Findings and Response to Letrozole in PCOS Patients
trial testing Letrozole tablets in PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries in 138 participants. Not yet recruiting.
1 December 2025
Quick facts
| Lead sponsor | Al-Azhar University |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 138 |
| Start date | 1 April 2025 |
| Primary completion | 1 December 2025 |
| Estimated completion | 30 December 2025 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Letrozole tablets — full drug profile →
Conditions studied
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries — all drugs for PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries →
Sponsor
Al-Azhar University
Who can join
Adults 18 to 40, female only, with PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to compare laboratory and ultrasound findings between letrozole-resistant and letrozole-sensitive PCOS patients in Egypt. The study will include women aged 18-40 years diagnosed with PCOS based on the Rotterdam criteria, who are undergoing ovulation induction with letrozole for the first time. The main questions it aims to answer are: What are the baseline laboratory and ultrasound differences between letrozole-resistant and letrozole-sensitive PCOS patients? What factors can predict letrozole resistance in PCOS patients? Researchers will compare letrozole-resistant and letrozole-sensitive PCOS patients to determine whether specific laboratory markers and ultrasound findings can predict resistance to letrozole. Participants will: Undergo baseline clinical, laboratory, and ultrasound assessments before starting letrozole treatment. Receive letrozole treatment with dose escalation up to 7.5 mg/day over a maximum of three cycles if ovulation is not achieved. Be monitored through serial transvaginal ultrasounds to assess follicular development. Have ovulation confirmed via mid-luteal serum progesterone levels. The study aims to improve the understanding of predictors of letrozole resistance to guide personalized ovulation induction strategies in PCOS patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06861803
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Related trials
Other trials of Letrozole tablets
Trials testing the same drug.
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- NCT07168837 — Letrozole and Cabergoline Versus Letrozole Alone in Ovulation Induction · NA · completed
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- NCT05601700 — Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial) · Phase 3 · recruiting
- NCT05198050 — Letrozole in Induction of Abortion of Anembryonic Pregnancy · NA · completed
Other recruiting trials for PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Currently open trials in the same condition.
- NCT07182526 — Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycys · Phase 2 · recruiting
- NCT05734287 — The Frequency of Polycystic Ovary Syndrome Among Young Reproductive Females Presenting With Hyperandrogenism: a Mixed Co · recruiting
- NCT06050265 — Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome · NA · active not recruiting
- NCT05819853 — Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome · Phase 3 · recruiting
- NCT05756023 — IVF\ICSI Outcome in Women With Polycystic Ovary Syndrome · NA · recruiting
Other Al-Azhar University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06861803 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Al-Azhar University
- Last refreshed: 21 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06861803.
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