Last reviewed · How we verify
Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: a Randomized Clinical Trial of Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies. The study evaluates the effectiveness and safety of continuous ablative radiofrequency, which uses heat energy to disrupt pain signals, and chemical denervation with absolute alcohol, which involves an injection to reduce pain transmission. Participants will be randomly assigned to one of the treatments, and their pain levels, mobility, and quality of life will be monitored over time to determine which method provides better pain relief.
Details
| Lead sponsor | Federal University of São Paulo |
|---|---|
| Phase | NA |
| Status | NOT_YET_RECRUITING |
| Enrolment | 288 |
| Start date | 2025-04 |
| Completion | 2026-12 |
Conditions
- Osteoarthritis Knee
- Chronic Pain
Interventions
- Continuous Ablative Radiofrequency
- Chemical Denervation with Absolute Alcohol
Primary outcomes
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score — 6 months
a validated questionnaire used to assess pain, stiffness, and physical function in patients with knee osteoarthritis. It consists of 24 items divided into three subscales: pain (5 items), stiffness (2 items), and physical function (17 items). Each item is rated on a Likert scale (0-4), with higher scores indicating greater pain, stiffness, and functional impairment. The total WOMAC score will be measured at baseline, 1 month, 3 months, and 6 months post-intervention to evaluate the effectiveness of the treatments in improving knee osteoarthritis symptoms.
Countries
Brazil