NCT06853834: CREBS

Comparative Diagnostic Yield of Endobronchial Cryo Biopsy vs Forceps Biopsy in Patients With Suspected Sarcoidosis

Recruiting now NA Last updated 3 March 2025

What this trial tests

NA trial testing Cryobiopsy with liquid nitrogen in Sarcoidosis Lung in 150 participants. Currently enrolling.

Timeline

1 January 2024

Primary endpoint
15 April 2025

30 April 2025

Quick facts

Lead sponsor	Sanjay Gandhi Postgraduate Institute of Medical Sciences
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	150
Start date	1 January 2024
Primary completion	15 April 2025
Estimated completion	30 April 2025
Sites	1 location across India

Drugs / interventions tested

• Cryobiopsy with liquid nitrogen
• Endobronchial Forceps Biopsy

Conditions studied

• Sarcoidosis Lung — all drugs for Sarcoidosis Lung →
• Pulmonary Sarcoidosis — all drugs for Pulmonary Sarcoidosis →

Sponsor

Sanjay Gandhi Postgraduate Institute of Medical Sciences

Who can join

18 and older, any sex, with Sarcoidosis Lung or Pulmonary Sarcoidosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Sarcoidosis is a multi-systemic granulomatous disease of unknown cause that is characterized by the formation of non-caseous epithelioid cell granulomas. Sarcoidosis involves the respiratory system in \> 90% of cases, usually the hilar and mediastinal nodes, and, less frequently, the lung tissue. Airway involvement, as judged by clinical features, physiologic testing, imaging techniques, bronchoscopy, and airway mucosal biopsy, has been observed in nearly two-thirds of patients with sarcoidosis. Although sarcoidosis involving thoracic lymph nodes and pulmonary parenchyma is familiar to most clinicians, airway involvement is often overlooked. The frequency of airway involvement increases as the parenchymal disease progresses, and\\airway involvement is associated with increased morbidity, respiratory symptoms, and mortality. The initial airway abnormality is the inflammation manifested by mucosal edema, erythema, and the formation of granulomas. As the airway disease progresses, the mucosa may demonstrate granularity, nodularity, cobble stoning, and friability. Sarcoid granulomas tend to develop along the bronchovascular bundle or in the vicinity of the airways. Overall quality of the endobronchial biopsy (EBB) will depend on the method by which it is obtained and cryo-EBB will most likely to provide better tissue for the diagnosis in comparison to forceps biopsy which has smaller sample as well as crush artifacts. Therefore, it is hypothesized that cryo-EBB will be better than forceps EBB and combined together it will increase the overall diagnostic yield of the sarcoidosis when combined with lymph node sampling by endobronchial ultrasound guided trans-bronchial needle aspiration (EBUS-TBNA).

1. Primary objective: To compare the diagnostic yield of cryo-EBB with forceps biopsy in patients undergoing routine EBUS-TBNA for suspected sarcoidosis.
2. Secondary Objective: To evaluate the overall diagnostic yield of combined endobronchial biopsy and EBUS-TBNA in patients undergoing routine EBUS-TBNA for suspected sarcoidosis.

The relevance and the expected outcome of the proposed study

1. The study will provide insight to obtain an endobronchial biopsy either with cryo probe or forceps
2. The study will also provide information regarding overall increase in diagnostic yield if any when the endobronchial biopsies are combined with EBUS-TBNA.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.