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NCT06847880
The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: A Randomized Clinical Trial
Phase 1 trial testing 1: Vitamin C Supplementation in Pain Perception in 51 participants. Completed in 28 February 2026.
28 February 2026
Quick facts
| Lead sponsor | University of Baghdad |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 51 |
| Start date | 23 February 2025 |
| Primary completion | 28 February 2026 |
| Estimated completion | 28 February 2026 |
| Sites | 3 locations across Iraq |
Drugs / interventions tested
- 1: Vitamin C Supplementation — full drug profile →
- Vitamin E Supplementation — full drug profile →
- Saline Solution (Control)
Conditions studied
- Pain Perception — all drugs for Pain Perception →
- Root Resorption — all drugs for Root Resorption →
- Rate of Orthodontic Tooth Movement — all drugs for Rate of Orthodontic Tooth Movement →
- Biomarkers — all drugs for Biomarkers →
Sponsor
University of Baghdad
Who can join
12 and older, any sex, with Pain Perception or Root Resorption. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brief Summary of the Study This study investigates the effects of locally administered vitamins C and E on orthodontic tooth movement during the initial stage of treatment. Orthodontic tooth movement relies on bone remodeling, which can be influenced by antioxidants like vitamins C and E. Vitamin C promotes collagen formation and osteoblast activity, while vitamin E has anti-inflammatory and antioxidant properties that may impact bone metabolism. The study is a randomized clinical trial conducted in multiple clinics, where patients will be divided into three groups: 1. Control group - receives a saline injection. 2. Vitamin C group - receives a local injection of vitamin C. 3. Vitamin E group - receives a local injection of vitamin E. Injections will be administered every two weeks for vitamin C and every month for vitamin E, for six months, while patients undergo orthodontic treatment with fixed appliances. Researchers will evaluate the rate of tooth movement, root resorption, pain perception, and patient experience. Additionally, biomarkers related to bone remodeling will be measured in gingival crevicular fluid at different time points. The study aims to determine whether local administration of vitamins C or E enhances orthodontic tooth movement and elevate their effects on the orthodontic potential side effects like root resorption and pain. The findings may provide valuable insights into optimizing orthodontic treatment with the help of antioxidants.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06847880
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other recruiting trials for Pain Perception
Currently open trials in the same condition.
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- NCT06841601 — Effectiveness of Vibratory Versus Cold Stimuli on Pain Perception in Children · NA · recruiting
Other University of Baghdad trials
Trials by the same sponsor.
- NCT07417839 — (Effect of Toy Nebulizer Versus Distraction Cards on Children's Fear and Parental Satisfaction During Nebulization Thera · NA · not yet recruiting
- NCT07456657 — Effect of Lavender Aromatherapy Massage on Pain and Wrist Mobility in Rheumatoid Arthritis · NA · not yet recruiting
- NCT07460089 — Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm Infants · NA · not yet recruiting
- NCT07350343 — The Predictability of Directly Printed Versus Thermoformed Clear Aligners · NA · enrolling by invitation
- NCT07362160 — Clear Orthodontic Expander Versus Hyrax · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06847880 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Baghdad
- Last refreshed: 2 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06847880.
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