NCT06847386 is a NA clinical trial of Hysterocopic metroplasty in Recurrent Implantation Failure, sponsored by Shanghai First Maternity and Infant Hospital.

Who is sponsoring NCT06847386?

NCT06847386 is sponsored by Shanghai First Maternity and Infant Hospital.

What drugs are being tested in NCT06847386?

Interventions in NCT06847386: Hysterocopic metroplasty.

What condition does NCT06847386 study?

NCT06847386 studies Recurrent Implantation Failure, T-Shaped Uterus.

Is NCT06847386 still recruiting?

NCT06847386 is currently enrolling by invitation. Last updated 26 February 2025.

Last reviewed 2025-02-26 · How we verify

NCT06847386

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Hysteroscopic Metroplasty on Reproductive Outcome in Patients with RIF

ENROLLING BY INVITATION NA Last updated 26 February 2025

What this trial tests

NA trial testing Hysterocopic metroplasty in Recurrent Implantation Failure in 200 participants. Enrolling by invitation.

Timeline

1 January 2022

Primary endpoint
31 May 2025

30 June 2025

Quick facts

Lead sponsor	Shanghai First Maternity and Infant Hospital
Phase	NA
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	200
Start date	1 January 2022
Primary completion	31 May 2025
Estimated completion	30 June 2025
Sites	1 location across China

Drugs / interventions tested

Hysterocopic metroplasty

Conditions studied

Recurrent Implantation Failure — all drugs for Recurrent Implantation Failure →
T-Shaped Uterus — all drugs for T-Shaped Uterus →

Sponsor

Shanghai First Maternity and Infant Hospital

Who can join

Adults 20 to 40, female only, with Recurrent Implantation Failure or T-Shaped Uterus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In recent years with the continuous improvement of ART technology, it has brought new hope to infertile couples, however more than half of the patients still experience multiple transfer failures. Abnormalities in the structure of the uterine cavity are one of the main factors that lead to the failure of embryo implantation. Hysteroscopic metroplasty with cold scissors is an innovative technique of our team, in which micro-scissors are used in the procedure instead of the previous electric knife. Our previous study found that this technique has the effect of improving fertility outcomes in patients with T-shaped uterus. Based on the previous study, this study is an open randomized controlled trial to include patients with more than 2 or more ART implantation failures. For the first time, cold knife hysteroscopic hysterectomy was used to treat patients with cryptic uterine stenosis in patients with repeated RIF implantation failures to assess the clinical efficacy of the technique and to investigate the effect of this technique on the pregnancy outcome of reimplantation of embryos in patients with repeated ART implantation failures. Meanwhile, this project is the first to study the diagnostic value of transvaginal 3D ultrasound/MRI for the assessment of uterine cavity status in patients with RIF, with a view to exploring the value of noninvasive imaging as an alternative to invasive hysteroscopy in the clinical management of RIF. The aim of the study is to provide a reference for early diagnosis and treatment of patients with repeated ART implantation failures, and to improve the pregnancy outcome of their reimplanted embryos.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Recurrent Implantation Failure

Currently open trials in the same condition.

NCT06762626 — Comparing FET Guided by ERA Vs Standard Timing in Patients with Recurrent Implantation Failure · NA · recruiting
NCT03900780 — Preimplantation Genetic Testing for Aneuploidies in Patients With Recurrent Implantation Failure · NA · recruiting
NCT05169541 — Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction · recruiting

Other Shanghai First Maternity and Infant Hospital trials

Trials by the same sponsor.

NCT07426146 — Feasibility Effects of a Low-GI, High-fibre Diet in PCOS: a Prospective Cohort Study in Remote Yunnan · recruiting
NCT06093984 — Cumulative Live Birth Rates in Dual Ovarian Stimulation Versus Two Antagonist Stimulations in Poor Ovarian Responders · NA · not yet recruiting
NCT06049186 — CRD vs. Met in Patients With Obese PCOS Infertility · NA · unknown
NCT06104748 — A Cohort of Maternal Vascular Malperfusion-related FGR (CoMVMFGR) · recruiting
NCT06096805 — Prediction of Placental Fetal Growth Restriction in High Risk Population (PoPFGR) · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06847386 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai First Maternity and Infant Hospital
Last refreshed: 26 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06847386.

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