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NCT06845852
A Phase 1 Mass Balance Study of Varegacestat
Phase 1 trial testing varegacestat in Healthy Volunteer in 6 participants. Completed in 26 March 2025.
11 March 2025
Quick facts
| Lead sponsor | Immunome, Inc. |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 6 |
| Start date | 25 February 2025 |
| Primary completion | 11 March 2025 |
| Estimated completion | 26 March 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- varegacestat — full drug profile →
Conditions studied
- Healthy Volunteer — all drugs for Healthy Volunteer →
Sponsor
Immunome, Inc. — full company profile →
Who can join
Adults 18 to 55, male only, with Healthy Volunteer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical study is designed to study the mass balance of a single dose of varegacestat in healthy male participants.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06845852
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of varegacestat
Trials testing the same drug.
- NCT06841315 — A Varegacestat Hepatic Impairment Study · Phase 1 · completed
- NCT06855264 — A Cardiac Liability Study of Varegacestat in Healthy Participants · Phase 1 · completed
- NCT06677996 — A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healt · Phase 1 · completed
Other recruiting trials for Healthy Volunteer
Currently open trials in the same condition.
- NCT06274749 — Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Mask · NA · recruiting
- NCT05652478 — Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study · Phase 2 · recruiting
- NCT06845176 — Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery · NA · recruiting
- NCT07439263 — Single Ascending Dose Study of HB2198 in Healthy Participants · Phase 1 · recruiting
- NCT07220122 — Impact of Exogenous Ketones on Breathing in Healthy Volunteers · EARLY_PHASE1 · recruiting
Other Immunome, Inc. trials
Trials by the same sponsor.
- NCT06841315 — A Varegacestat Hepatic Impairment Study · Phase 1 · completed
- NCT06855264 — A Cardiac Liability Study of Varegacestat in Healthy Participants · Phase 1 · completed
- NCT06677996 — A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healt · Phase 1 · completed
- NCT05429021 — IMM-BCP-01 in Mild to Moderate COVID-19 · Phase 1 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06845852 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Immunome, Inc.
- Last refreshed: 26 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06845852.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing