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NCT06844851: GenetiCA
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: from Patients to Families
trial in Cardiac Arrest (CA) in 1,725 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,725 |
| Start date | 9 September 2021 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across Italy |
Conditions studied
- Cardiac Arrest (CA) — all drugs for Cardiac Arrest (CA) →
Sponsor
Fondazione IRCCS Policlinico San Matteo di Pavia
Who can join
Adults 18 to 50, any sex, with Cardiac Arrest (CA). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aims are to define the exact prevalence of hereditary heart diseases in out-of-hospital cardiac arrest (OHCA) patients taking also into account gender, patient and OHCA characteristics, provincial settings and environmental pollution; to stratify the individualized arrhythmic risk of proband's family members to prevent further sudden cardiac deaths; to refine the classification of the variants of uncertain significance (VUS) on genes which can have the capability to drive to molecular alterations leading to arrhythmogenic hereditary heart diseases. A blood sample will be obtained during resuscitation from all the patients aged ≤50 years suffering an OHCA in Lombardy Region and then analysed for genetic variants possibly causative of cardiac diseases. Genetic data will be merged with patient, OHCA and post-resuscitation data thanks to the connection with LombardiaCARe, whilst pollution data will be retrieved from ARPA Lombardia for free. A genetic counselling and clinical-instrumental evaluation of the proband's first-degree family members will be performed if a pathogenic/likely pathogenic variant or a VUS will be disclosed during the genetic analysis.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Evaluation of genetic-molecular causes of out-of-hospital cardiac arrest - from patients to families: the GenetiCA study.
Morena A, Bendotti S, D'Ambrosio A, Marconi G, et al · · 2026 · PMID 42199521 · DOI 10.1016/j.resplu.2026.101351 -
Evaluation of genetic-molecular causes of out-of-hospital cardiac arrest – from patients to families: the GenetiCA study
Morena A, Bendotti S, D’Ambrosio A, Marconi G, et al · · 2026
Verify or expand the search:
- PubMed search for NCT06844851
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06844851 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione IRCCS Policlinico San Matteo di Pavia
- Last refreshed: 25 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06844851.
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