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NCT06842940: SLEW REGISTRY
Slew Rate As a Predictor for Optimal Lead Fixation
trial in Defibrillators, Implantable in 516 participants. Currently enrolling.
28 February 2026
Quick facts
| Lead sponsor | Paolo Pastori, MD |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 516 |
| Start date | 18 February 2023 |
| Primary completion | 28 February 2026 |
| Estimated completion | 28 February 2027 |
| Sites | 1 location across Italy |
Conditions studied
- Defibrillators, Implantable — all drugs for Defibrillators, Implantable →
- Electrodes, Implanted — all drugs for Electrodes, Implanted →
- Pacemaker, Artificial — all drugs for Pacemaker, Artificial →
- Predictive Value of Tests — all drugs for Predictive Value of Tests →
Sponsor
Paolo Pastori, MD
Who can join
Adults 18 to 100, any sex, with Defibrillators, Implantable or Electrodes, Implanted. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to identify the most reliable electrical parameter measured at the time of implantation that can predict optimal lead fixation and long-term lead performance in patients undergoing transvenous pacemaker or implantable cardioverter-defibrillator (ICD) implant. The main questions it aims to answer are: * Is there a correlation between the slew rate measured at the time of lead implantation and the sensing measured at the 12-month follow-up? * Is there a correlation between all electrical parameters recorded at implantation (including slew rate, current of injury, acute sensing, acute impedance, and acute pacing threshold) and the electrical parameters assessed at 12 months post-implantation (specifically chronic sensing, chronic impedance, and chronic pacing threshold)? Participants will undergo regular follow-up evaluations, with device interrogation visits scheduled at 1 and 12 months post-implantation as part of routine clinical care.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06842940
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Defibrillators, Implantable
Currently open trials in the same condition.
- NCT06739239 — French COhoRte Extra-Vascular Implantable CardiovErter DefibrillatoR · recruiting
- NCT06597578 — Prospective Köln Bonn Registry for the Extraction of Pacmaker and ICD Leads · recruiting
- NCT06330675 — Correct Mobilization Time After Implantation of an Intracardiac Electronic Device Implantation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06842940 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Paolo Pastori, MD
- Last refreshed: 24 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06842940.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing