Investigating the Neural Signature of Freezing of Gait Using Ambulatory Electroencephalography in Parkinson's Disease (FOG-EEG)

NCT06841718 ENROLLING_BY_INVITATION

Freezing of Gait (FOG) is a disabling symptom of Parkinson's disease (PD) and a leading cause for falls. Current medical management is inadequate to alleviate FOG so there is need for improved treatments. A major draw-back in the development of better treatments for FOG is the difficulty in detecting episodes and our poor understanding of its underlying pathophysiology. This study will investigate the cortical signature of FOG using ambulatory electroencephalography (EEG) to help improve FOG detection algorithms and provide novel insights into the underlying pathophysiology, which together will guide therapy development.

Details

Lead sponsor	KU Leuven
Status	ENROLLING_BY_INVITATION
Enrolment	28
Start date	2024-11-04
Completion	2026-09

Conditions

• Parkinson Disease
• Freezing of Gait
• Basal Ganglia Diseases
• Brain Disease
• Movement Disorders
• Neurodegenerative Disease

Primary outcomes

• Power spectral density (Watts/hertz) of beta frequencies — During walking protocol (duration 15-20 minutes)
  The averaged power spectral density (PSD) of the beta (12-25 Hz) frequency band measured over the motor cortices during freezing of gait (FOG) episodes compared to typical gait performance in the same individual with Parkinson's disease as measured during different walking trajectories in the home setting.

Countries

Belgium