NCT06838975: NeuroVR

Virtual Reality Rehabilitation for Cognitive, Emotional, and Motor Recovery in Neurological Disorders

Active, enrolled NA Last updated 21 February 2025

What this trial tests

NA trial testing VR Training in Acquired Brain Injuries in 328 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

16 January 2025

Primary endpoint
29 September 2027

31 January 2028

Quick facts

Lead sponsor	IRCCS Centro Neurolesi Bonino Pulejo
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	328
Start date	16 January 2025
Primary completion	29 September 2027
Estimated completion	31 January 2028
Sites	2 locations across Italy

Drugs / interventions tested

• VR Training
• traditional cognitive and motor rehabilitation following standard clinical practices

Conditions studied

• Acquired Brain Injuries — all drugs for Acquired Brain Injuries →
• Spinal Cord Injury — all drugs for Spinal Cord Injury →
• Multiple Sclerosis — all drugs for Multiple Sclerosis →
• Parkinson Disease — all drugs for Parkinson Disease →

Sponsor

IRCCS Centro Neurolesi Bonino Pulejo — full company profile →

Who can join

Adults 18 to 75, any sex, with Acquired Brain Injuries or Spinal Cord Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This randomized controlled trial (RCT) evaluates the effectiveness of virtual reality (VR) rehabilitation in improving cognitive, emotional, social, and motor functions in patients with neurological disorders (ABI, SCI, MS, PD). It investigates whether VR improves motor and cognitive functions more than traditional therapy, identifies neurophysiological changes (EEG, fNIRS, MRI), and assesses the integration of VR with NIBS or telerehabilitation. Conducted over three years at IRCCS Centro Neurolesi Bonino Pulejo, participants are randomly assigned to either a VR training group or an active control group receiving traditional rehabilitation. Procedures include baseline assessments (T0), 20 rehabilitation sessions over 8 weeks, post-intervention evaluations (T1), and a 3-month follow-up (T2). Primary outcomes measure motor and cognitive function (MoCA, MMSE, FIM, TUG, Berg Balance Scale), neurophysiological changes (EEG, MRI, fNIRS, motion analysis), and emotional/social function (Empathy Quotient, Hamilton Depression Scale).

Publications & conference data

No peer-reviewed publications indexed yet for this trial.