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NCT06836830: PerAVent
PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
NA trial testing PEEP 5 mbar in Ventilation Therapy in 600 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Muehlenkreiskliniken, MKK |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | health services research |
| Enrollment | 600 |
| Start date | 1 June 2025 |
| Primary completion | 30 June 2026 |
| Estimated completion | 31 October 2026 |
| Sites | 3 locations across Germany |
Drugs / interventions tested
- PEEP 5 mbar
- ZEEP 0 mbar
Conditions studied
- Ventilation Therapy — all drugs for Ventilation Therapy →
- PEEP, Occult — all drugs for PEEP, Occult →
- CPR — all drugs for CPR →
- Cardiac Arrest (CA) — all drugs for Cardiac Arrest (CA) →
Sponsor
Muehlenkreiskliniken, MKK
Who can join
18 and older, any sex, with Ventilation Therapy or PEEP, Occult. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Peri-arrest ventilation with positive end-expiratory-pressure vs. zero end-expiratory-pressure in out-of-hospital-cardiac-arrest (PerAVent)-a prospective, cluster-randomized multicenter trial.
Vaseekaran M, Vollmer T, Kolaparambil Varghese LJ, Zeichen C, et al · · 2026 · PMID 41566395 · DOI 10.1186/s13063-025-09292-w -
Peri-Arrest Ventilation with Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest (PerAVent) – a prospective, cluster-randomized multicenter trial
Vaseekaran M, Vollmer T, Zeichen C, Hinkelbein J, et al · · 2025 · DOI 10.21203/rs.3.rs-6140784/v1
Verify or expand the search:
- PubMed search for NCT06836830
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Muehlenkreiskliniken, MKK trials
Trials by the same sponsor.
- NCT06885398 — Intra Arrest Ventilation in Human Cadavers II · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06836830 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Muehlenkreiskliniken, MKK
- Last refreshed: 6 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06836830.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing