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NCT06835166
Effect of Intraoperative Position Change on Hemodynamics and Electrocardiography
trial testing 12-lead electrocardiography measurement in Bariatric Surgery (Sleeve Gastrectomy ) in 80 participants. Completed in 20 May 2025.
25 April 2025
Quick facts
| Lead sponsor | Firat University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 10 February 2025 |
| Primary completion | 25 April 2025 |
| Estimated completion | 20 May 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- 12-lead electrocardiography measurement
Conditions studied
- Bariatric Surgery (Sleeve Gastrectomy ) — all drugs for Bariatric Surgery (Sleeve Gastrectomy ) →
- Hemodynamics — all drugs for Hemodynamics →
- Electrocardiography — all drugs for Electrocardiography →
Sponsor
Firat University
Who can join
Adults 18 to 65, any sex, with Bariatric Surgery (Sleeve Gastrectomy ) or Hemodynamics. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The combined effects of obesity-related cardiac structure and function changes, comorbidities, pneumoperitoneum technique, and reverse Trendelenburg position may complicate anesthesia management by affecting intraoperative hemodynamics and cardiac function. Increased intra-abdominal pressure leads to various physiological changes through mechanical and neurohormonal responses. Furthermore, pneumoperitoneum and reverse Trendelenburg position are reported to stimulate the sympathetic nervous system and increase the risk of cardiac arrhythmia. Obesity-related changes in cardiac structure and function have been shown to predispose to cardiac conduction and repolarization disorders. It has also been stated that obesity directly affects cardiac electrophysiology. Moreover, obese patients may have hidden risks associated with the development of cardiac arrhythmias due to the adverse contributions of the cardiovascular effects of anesthesia, pneumoperitoneum, and patient positioning during laparoscopic intervention. The index of cardiac electrophysiological balance (iCEB) is a non-invasive marker calculated by the QT/QRS ratio that can predict malignant ventricular arrhythmias. The aim of this study was to investigate the effects of intraoperative patient positions on hemodynamics and the index of cardiac electrophysiological balance (iCEB) during laparoscopic sleeve gastrectomy in morbidly obese patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Impact of Intraoperative Position Changes on Hemodynamics and Cardiac Electrophysiological Balance Index in Patients with Severe Obesity Undergoing Laparoscopic Sleeve Gastrectomy.
Celik F, Dagli R, Aksu A, Harman M, et al · · 2026 · PMID 41619101 · DOI 10.1007/s11695-026-08497-5
Verify or expand the search:
- PubMed search for NCT06835166
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06835166 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Firat University
- Last refreshed: 16 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06835166.
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