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NCT06832878
Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty
Phase 4 trial testing Oral Tranexamic Acid in Arthroplasty in 101 participants. Not yet recruiting.
1 June 2026
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 101 |
| Start date | 1 June 2026 |
| Primary completion | 1 June 2026 |
| Estimated completion | 1 June 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Oral Tranexamic Acid
Conditions studied
- Arthroplasty — all drugs for Arthroplasty →
Sponsor
Mayo Clinic
Who can join
18 and older, any sex, with Arthroplasty. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Visual Analog Score
Time frame: Baseline, 3 days postoperative, 2 weeks, 6 weeks, 12 weeks
The VAS is a 11-item questionnaire assessing pain. Using a scale of 0 = no pain to 10 = worst pain. Total scores range from 0 - 110, lower scores indicating lower pain and higher scores indicating greater pain. -
Hip Disability and Osteoarthritis Outcome Score (HOOS) for Joint Replacement (JR)
Time frame: Baseline, 3 days postoperative, 2 weeks, 6 weeks, 12 weeks
The Hip Disability and Osteoarthritis Outcome Score (HOOS) for Joint Replacement (JR) is a questionnaire designed to measure outcomes for patients with hip replacements. Results are scored 0-11. 0 = total hip disability, 100 = perfect hip health.
Sponsor's own description
The purpose of this study is to evaluate the impact of an extended oral Tranexamic Acid regimen on patient reported outcome scores, time to independent ambulation, postoperative range of motion, swelling, change in hemoglobin levels, 90-day complications, readmission and reoperation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06832878
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Oral Tranexamic Acid
Trials testing the same drug.
- NCT03585179 — Oral and Topical Tranexamic Acid for the Treatment of Melasma · Phase 3 · unknown
- NCT03365999 — Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement. · Phase 2 · completed
Other recruiting trials for Arthroplasty
Currently open trials in the same condition.
- NCT07425457 — Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial) · NA · recruiting
- NCT06323980 — INHANCE Stemless Reverse Shoulder IDE · NA · recruiting
- NCT04848896 — Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedur · NA · recruiting
- NCT04849884 — To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System. · NA · active not recruiting
- NCT05190666 — Healthy Living After Knee Replacement · NA · active not recruiting
Other Mayo Clinic trials
Trials by the same sponsor.
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- NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
- NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
- NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06832878 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 29 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06832878.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing