Last reviewed · How we verify
NCT06826092
Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy
Phase 2 trial testing Metformin Pill in Progression-Free Survival in 110 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 110 |
| Start date | 31 October 2022 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Metformin Pill — full drug profile →
- FOLFIRI plus target therapy only — full drug profile →
Conditions studied
- Progression-Free Survival — all drugs for Progression-Free Survival →
Sponsor
Kaohsiung Medical University Chung-Ho Memorial Hospital
Who can join
Adults 20 to 90, any sex, with Progression-Free Survival. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To investigate progression-free survival (PFS) in patients with metastatic colorectal cancer treated with chemotherapy FOLFIRI monotherapy or chemotherapy FOLFIRI combined with Metformin
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy.
Zhang H, Fan J, Kong D, Sun Y, et al · · 2025 · cited 8× · PMID 41063213 · DOI 10.1186/s12943-025-02460-1
Verify or expand the search:
- PubMed search for NCT06826092
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Metformin Pill
Trials testing the same drug.
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- NCT04508634 — Treating Obese PCOS Patients With LSG vs. Met · Phase 4 · unknown
- NCT03253562 — Metformin Versus Vildagliptin for Diabetic Hypertensive Patients · Phase 4 · completed
Other recruiting trials for Progression-Free Survival
Currently open trials in the same condition.
- NCT06527001 — Mesenteric Lymph Node Metastasis and Nutritional Status After Bowel Resection for Ovarian Cancer · active not recruiting
- NCT05024175 — Long-term Follow-up of Subjects Treated With CAR T Cells · recruiting
Other Kaohsiung Medical University Chung-Ho Memorial Hospital trials
Trials by the same sponsor.
- NCT07342426 — High and Low Dose High-intensity Laser Therapy Lateral Epicondylitis · Phase 4 · recruiting
- NCT07346469 — Exploring the Effects of Magnesium Ions on Peripheral Neuropathy, Serum Magnesium Ion Concentration,Sleep Quality, and Q · NA · not yet recruiting
- NCT07154407 — AI-assisted Masticatory Muscle Training in Patients With Schizophrenia · NA · not yet recruiting
- NCT07154628 — Effect of Topical Lidocaine Spraying on the Vocal Cords Before Intubation During Robotic Surgery: a Randomized Controlle · Phase 4 · not yet recruiting
- NCT07126444 — Effects of an Exercise Snack Intervention on Employee Health and Work Performance · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06826092 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kaohsiung Medical University Chung-Ho Memorial Hospital
- Last refreshed: 13 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06826092.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing