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NCT06825741
Brain Structural Abnormalities in Patients with Post-COVID-19 Headache
trial testing Observational Study - No intervention in COVID-19 in 60 participants. Completed in 31 December 2022.
31 December 2022
Quick facts
| Lead sponsor | University of Pecs |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 1 September 2020 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across Hungary |
Drugs / interventions tested
- Observational Study - No intervention
Conditions studied
Sponsor
University of Pecs
Who can join
18 and older, any sex, with COVID-19 or Headache. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction: The clinical manifestations of the COVID-19 pandemic are heterogeneous and may include various symptoms (gastrointestinal, musculoskeletal, neurological). Approximately 25% of patients report headache as a neurological symptom, making it the fifth most common symptom. These headaches may arise from structural brain changes associated with the infection. Purpose: This study aims to identify the structural abnormalities observed in brain MRI that correlate with chronic headaches in patients who had COVID-19 infection. Methods: The study included 30 patients with post-COVID-19 headaches and 30 control patients with no history of COVID-19. Demographic characteristics were analyzed using t-tests and chi-square tests. MRI findings were categorized into six types: cortical atrophy, white matter lesions, vascular lesions, lacunar lesions, vascular encephalopathy, and sinusitis. Differences in MRI findings between the two groups were evaluated using chi-square tests. Secondary outcomes included the analysis of symptoms accompanying headaches, diagnoses following MRI, and treatments applied.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Brain Structural Abnormalities in Patients with Post-COVID-19 Headache.
Széphelyi K, Kóra S, Orsi G, Tollár J. · · 2025 · cited 1× · PMID 40278421 · DOI 10.3390/neurolint17040050
Verify or expand the search:
- PubMed search for NCT06825741
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06825741 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pecs
- Last refreshed: 17 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06825741.
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