Last reviewed · How we verify
NCT06822127: SPOC
Simulation of Facial Soft Tissue in Orthognathic Surgery
NA trial testing CT scan in Orthognathic Surgery in 30 participants. Currently enrolling.
31 October 2027
Quick facts
| Lead sponsor | Centre Hospitalier Annecy Genevois |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 30 |
| Start date | 28 April 2025 |
| Primary completion | 31 October 2027 |
| Estimated completion | 31 October 2027 |
| Sites | 1 location across France |
Drugs / interventions tested
- CT scan — full drug profile →
- VLASTIC test
Conditions studied
- Orthognathic Surgery — all drugs for Orthognathic Surgery →
Sponsor
Centre Hospitalier Annecy Genevois
Who can join
18 and older, any sex, with Orthognathic Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Orthognathic surgery consists of rebalancing the position of the jaws, taking into account functional criteria (tooth engagement, tooth/lip ratio, breathing, etc.) and aesthetic criteria. It has become much more accurate in recent years thanks to the advent of osteosynthesis plates and the contribution of three-dimensional imaging. Three-dimensional imaging makes it possible to simulate fairly accurately the surgical procedures and bone displacements required. However, the effect of these bone displacements on the soft tissues (skin, subcutaneous tissue, muscles) does not make it possible, with today's digital tools, to simulate the final aesthetic result and in particular to anticipate the sometimes significant postoperative changes to the face. Many patients are worried about these post-operative morphological changes and would like to have a precise idea of how they will look after surgery. Being able to offer them, before surgery, a visual solution simulating the final aesthetic appearance would be essential in this respect. The aim of the study is to validate the predictions provided by the digital face model on a series of patients scheduled for orthognathic surgery by comparing the simulation of the morphological result of the operation, provided by our algorithm (SPOC), with the actual result assessed on a scan taken 6 months after the operation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Clinically Compatible Method for Generating Preoperative Finite Element Models to Simulate Facial Appearance and Movements in Orthognathic Surgery.
Picard MC, Nazari MA, Perrier P, Bettega G, et al · · 2026 · cited 2× · PMID 41641463 · DOI 10.1002/cnm.70144
Verify or expand the search:
- PubMed search for NCT06822127
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06822127 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Annecy Genevois
- Last refreshed: 17 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06822127.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing