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NCT06821308
A Randomized Controlled Clinical Trial to Assess Crestal Bone Remodeling of Four Different Implant Designs
NA trial testing Implant placement in Dental Implant Bone Loss in 25 participants. Completed in 20 February 2024.
20 February 2024
Quick facts
| Lead sponsor | University Ghent |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 25 |
| Start date | 18 September 2015 |
| Primary completion | 20 February 2024 |
| Estimated completion | 20 February 2024 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Implant placement
Conditions studied
- Dental Implant Bone Loss — all drugs for Dental Implant Bone Loss →
Sponsor
University Ghent
Who can join
21 and older, any sex, with Dental Implant Bone Loss. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial aimed to assess the effect of the implant neck design (microthreaded vs. non-microthreaded) as well as the type of abutment connection (internal conical vs. external flat-to-flat) on long-term crestal bone remodelling and peri-implant health. Four implants used for a bar-retained maxillary overdenture, were followed over a period of at least 6 years. Twenty-five patients were treated with a bar-retained maxillary overdenture. Four different implants were placed, with respectively: internal connection and microthreads on the implant neck (I MT); internal connection, without microthreads (I NMT); external connection, with microthreads (E MT); and external connection, without microthreads (E NMT). Other design features, s.a. diameter, surface topography, extent of platform switch as well as the surgical and prosthetic treatment protocol were identical. Radiographic crestal bone loss (CBL), plaque score (PS), bleeding on probing (Bop) and probing pocket depth (PPD) were determined at 1 and 6 years after implant placement.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A 6-Year Randomized Controlled Trial on Different Implant Designs in Maxillary Overdenture Patients.
Matthijs S, Christiaens V, Matthys C, De Bruyn H, et al · · 2025 · cited 1× · PMID 40552788 · DOI 10.1111/cid.70069
Verify or expand the search:
- PubMed search for NCT06821308
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06821308 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Ghent
- Last refreshed: 11 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06821308.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing