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NCT06820047
Sleeve Gastrectomy vs. Lifestyle & Medications: Impact on BMI Trajectory and Target Attainment in a Matched Cohort Study
trial testing Laparoscopic sleeve gastrectomy in Obesity and Obesity-related Medical Conditions in 190 participants. Completed in 1 July 2024.
1 July 2023
Quick facts
| Lead sponsor | University of Roma La Sapienza |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 190 |
| Start date | 1 May 2022 |
| Primary completion | 1 July 2023 |
| Estimated completion | 1 July 2024 |
| Sites | 2 locations across Italy |
Drugs / interventions tested
- Laparoscopic sleeve gastrectomy
- Obesity pharmacotherapy — full drug profile →
Conditions studied
- Obesity and Obesity-related Medical Conditions — all drugs for Obesity and Obesity-related Medical Conditions →
Sponsor
University of Roma La Sapienza
Who can join
Adults 19 to 69, any sex, with Obesity and Obesity-related Medical Conditions. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obesity is a widespread and preventable condition affecting over a billion people globally, with rates expected to rise significantly by 2030. It increases the risk of chronic illnesses such as diabetes, cardiovascular disease, certain cancers, mental health issues, and premature death. While bariatric surgery, such as sleeve gastrectomy (SG), is the most effective long-term weight-loss solution, many individuals are ineligible or unwilling to undergo surgery. Semaglutide, a medication that suppresses appetite and aids in weight loss when paired with diet and exercise, offers a promising alternative. This study compared the effectiveness of SG and an intensive weight-loss program combining diet, exercise, and semaglutide. Conducted over a year with 190 participants split into two groups matched by BMI, the SG group underwent surgery, while the other group followed a calorie-restricted diet, intensive exercise, and weekly semaglutide injections. Changes in BMI, weight, and comorbidities such as diabetes and high blood pressure were evaluated, aiming to determine which approach was more effective in managing obesity.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of Sleeve Gastrectomy Versus Intensive Lifestyle Modifications With Obesity Management Medications on BMI Trajectory and Target Attainment: A Prospective Matched Cohort Study.
Russo MF, Casella G, Angelini G, Russo S, et al · · 2026 · PMID 42219275 · DOI 10.1111/dom.70912
Verify or expand the search:
- PubMed search for NCT06820047
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06820047 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Roma La Sapienza
- Last refreshed: 11 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06820047.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing