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DBS for Cognitive Deficits After Traumatic Brain Injury
Patients with memory and cognitive deficits following TBI that do not respond to conventional treatments experience a decrease in quality of life. Despite advances in neuroimaging, genetics, pharmacology and psychosocial interventions in the last half century, little progress has been made in altering the natural history of the condition or its outcome. This study would explore whether a surgical therapy is safe and potentially effective in patients who develop refractory memory and cognitive deficits following TBI. Preclinical studies suggest that DBS may improve memory deficits in TBI models. Moreover, DBS delivered to the fornix has shown promising clinical results in patients with Alzheimer's disease. The main mechanism for the improvements induced by DBS in memory tests is the development of multiple forms of plasticity.
Details
| Lead sponsor | Sunnybrook Health Sciences Centre |
|---|---|
| Phase | PHASE1 |
| Status | RECRUITING |
| Enrolment | 10 |
| Start date | Fri Nov 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sun Nov 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- TBI Traumatic Brain Injury
Interventions
- Deep Brain Stimulation
Countries
Canada