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NCT06817681
Exercise-Induced Lactate and Cognitive Function (ExLBC)
NA trial testing Sodium Bicarbonate (NaHCO3) in Cognition in 32 participants. Not yet recruiting.
30 July 2025
Quick facts
| Lead sponsor | McMaster University |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 32 |
| Start date | 10 February 2025 |
| Primary completion | 30 July 2025 |
| Estimated completion | 20 September 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Sodium Bicarbonate (NaHCO3) — full drug profile →
- Placebo (Sodium Chloride)
Conditions studied
- Cognition — all drugs for Cognition →
- Sodium Bicarbonate — all drugs for Sodium Bicarbonate →
- Lactate — all drugs for Lactate →
- Exercise — all drugs for Exercise →
Sponsor
McMaster University
Who can join
Adults 18 to 35, any sex, with Cognition or Sodium Bicarbonate. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A single bout of exercise can rapidly improve cognitive functions including memory, attention, and executive functions, which help us navigate through everyday life. However, we do not fully understand the mechanism behind this process. A promising candidate mechanism is lactate, which was previously considered merely a waste product of our muscles during exercise. It is now recognized as an important molecule that is used by the brain as an energy source. Studies have shown that increases in lactate during exercise are positively related to improved cognitive function after completion of exercise. Another potential mechanism involves the increase in neurotrophins such as brain-derived neurotrophic factor (BDNF) following exercise. The increase in lactate and BDNF during exercise may be connected to cause these cognitive improvements. However, because lactate increases with higher exercise intensities, we currently do not know how lactate specifically impacts brain health. To address this, muscle and blood lactate concentrations can be experimentally manipulated during exercise using sodium bicarbonate (NaHCO3) supplementation and will allow us to explore how lactate specifically affects brain function. The purpose of this project is to investigate the effect of exercise-induced lactate on BDNF and cognition following oral NaHCO3 supplementation in young adults. We hypothesize that BDNF levels will be higher, and cognition will be improved in executive function, visuospatial memory, and working memory in the NaHCO3 condition due to higher plasma lactate during exercise compared to placebo.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06817681
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06817681 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McMaster University
- Last refreshed: 10 February 2025
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