NCT06816459

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

Recruiting now EARLY_PHASE1 Last updated 6 April 2026

What this trial tests

EARLY_PHASE1 trial testing Cigarette smell test in Cigarette Smoking-Related Carcinoma in 30 participants. Currently enrolling.

Timeline

14 October 2025

Primary endpoint
14 October 2027

14 October 2027

Quick facts

Lead sponsor	Roswell Park Cancer Institute
Phase	EARLY_PHASE1
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	basic science
Enrollment	30
Start date	14 October 2025
Primary completion	14 October 2027
Estimated completion	14 October 2027
Sites	1 location across United States

Drugs / interventions tested

• Cigarette smell test
• Cigarette Taste Test
• Study questionnaires

Conditions studied

• Cigarette Smoking-Related Carcinoma — all drugs for Cigarette Smoking-Related Carcinoma →

Sponsor

Roswell Park Cancer Institute

Who can join

Adults 21 to 55, any sex, with Cigarette Smoking-Related Carcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This clinical trial tests how well current daily smoking adults can identify flavors of cigarettes. Menthol cigarettes account for 31 percent of cigarettes sold in the United States. Flavors such as menthol play an important role in the start and continued use of tobacco products. Two ways users experience flavor is through smell and taste. Menthol has cooling and numbing properties that can increase perceptions of smoothness and reduce the perceived harshness of smoke. Menthol adds a taste and aroma commonly described as "minty". The effect of menthol flavoring on smoking behavior has been studied. Use of menthol cigarettes has been associated with greater nicotine dependence and is associated with both fewer quit attempts and lower odds of quit success. In 2022, the Food and Drug Administration proposed to restrict the use of menthol as a flavor in cigarettes. Menthol has already been banned in Canada, the United Kingdom and the European Union. In late 2022, a restriction on all flavored tobacco products went into effect in California (CA), prompting the tobacco industry to introduce substitute products that did not contain menthol. It is important to find out whether New York (NY) adult smokers who smoke menthol cigarettes can identify and characterize flavors in the same cigarette brand as sold in NY versus CA following the ban of menthol cigarettes in 2022.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.