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NCT06812481
Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis
trial testing Anticholinergic load was calculated using anticholinergic cognitive load (ACB) in Rheumatoid Arthritis (RA) in 100 participants. Currently enrolling.
28 November 2025
Quick facts
| Lead sponsor | Balikesir University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 15 September 2025 |
| Primary completion | 28 November 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Anticholinergic load was calculated using anticholinergic cognitive load (ACB)
Conditions studied
- Rheumatoid Arthritis (RA) — all drugs for Rheumatoid Arthritis (RA) →
- Anticholinergic Adverse Reaction — all drugs for Anticholinergic Adverse Reaction →
- Fractures, Bone — all drugs for Fractures, Bone →
Sponsor
Balikesir University
Who can join
18 and older, any sex, with Rheumatoid Arthritis (RA) or Anticholinergic Adverse Reaction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory rheumatological disease. Use of corticosteroids for more than 3 months in RA treatment is considered an important risk factor in terms of developing secondary osteoporosis and increasing the risk of fracture. The cumulative effect of taking one or more drugs with anticholinergic properties is called anticholinergic load. It is stated that anticholinergic load also increases the risk of fracture in individuals. The aim of this study is to investigate the effects of drugs used by patients with Rheumatoid Arthritis (RA) on anticholinergic load and fracture risk. The Fracture Risk Assessment Tool (FRAX) will be used to assess fracture risk in patients. Materials and methods: The study was planned as a prospective cohort study. The study will included 100 patients who were followed up as outpatients with rheumatoid arthritis diagnosis in the physical medicine and rehabilitation clinic between 2024-2025. Patients of both genders and over 18 years of age diagnosed with rheumatoid arthritis will be included in the study. Patients with systemic diseases or medications affecting bone metabolism and those with metallic materials in the hip or lumbar vertebrae affecting bone mineral density measurement will be excluded from the study. Demographic characteristics, systemic diseases, medications used, bone density measurement and blood test values of the patients will be recorded. Patients taking multiple medications with anticholinergic effects create an anticholinergic burden. The Anticholinergic Drug Scale, Anticholinergic Cognitive Burden Scale and Anticholinergic Risk Scale will be used to measure anticholinergic burden in the study.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06812481
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06812481 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Balikesir University
- Last refreshed: 18 September 2025
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