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NCT06809972: 2BEGIN
Synovial Proliferation on Routine Ultrasound: Active or Inactive?
trial testing Ultrasound imaging in Haemophilia in 46 participants. Not yet recruiting.
1 June 2025
Quick facts
| Lead sponsor | Van Creveldkliniek |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 46 |
| Start date | 1 February 2025 |
| Primary completion | 1 June 2025 |
| Estimated completion | 21 December 2025 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Ultrasound imaging
Conditions studied
- Haemophilia — all drugs for Haemophilia →
- Hemophilia A — all drugs for Hemophilia A →
- Hemophilia B — all drugs for Hemophilia B →
Sponsor
Van Creveldkliniek
Who can join
12 and older, male only, with Haemophilia or Hemophilia A. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There is cumulating evidence for the presence of non-observed or subclinical joint bleeding in patients with haemophilia. Early detection of active subclinical synovial proliferation would allow early intervention in order to prevent deterioration of joint health. Patients with subclinical (=non-observed) signs of synovial proliferation in knee(s), ankle(s) and/or elbow(s) will be invited to participate in this study to further characterize the synovial proliferation status (active or inactive) by means of physical examination, MRI, ultrasound and elastography. Synovial proliferation status will be monitored for a maximum period of 12 weeks, during which participants will also receive standard-of-care treatment, i.e. administration of optimized coagulation factor replacement therapy and prescription of the NSAID celecoxib (optional).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06809972
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Van Creveldkliniek trials
Trials by the same sponsor.
- NCT07042178 — The Influence of Virtual Reality on Blood Parameters · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06809972 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Van Creveldkliniek
- Last refreshed: 5 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06809972.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing