Who is sponsoring TAFA-FIRST?

TAFA-FIRST is sponsored by Tafalgie Therapeutics.

What drugs are being tested in TAFA-FIRST?

Interventions: TT5, Placebo - TT5 vehicle.

What is the status of TAFA-FIRST?

TAFA-FIRST is currently RECRUITING.

Last reviewed 2026-03-18 · How we verify

A First in Human Study of TT5 in Single and Multiple Ascending Doses in Healthy Volunteers and Surgical Patients (TAFA-FIRST)

NCT06789861 PHASE1 RECRUITING

This study is a First in Human, three-parts, double-blind, randomized, placebo-controlled, single and multiple ascending dose study. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of TT5 at different doses in healthy and surgical participants.

Details

Lead sponsor	Tafalgie Therapeutics
Phase	PHASE1
Status	RECRUITING
Enrolment	94
Start date	Fri May 23 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Nov 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Pain

Interventions

TT5
Placebo - TT5 vehicle

Countries

Australia