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NCT06786780: ECCO

Establishment and Validation of Prediction Model of Simultaneous Chemoradiotherapy for Cervical Cancer Organoids

ENROLLING BY INVITATION Phase 2 Last updated 26 March 2025
What this trial tests

Phase 2 trial testing Drug: Cisplatin in Cervical Cancer Treated with Pelvic Radiotherapy in 50 participants. Enrolling by invitation.

Timeline
1 January 2023
Primary endpoint
1 June 2025
1 June 2026

Quick facts

Lead sponsorChongqing University Cancer Hospital
PhasePhase 2
StatusENROLLING BY INVITATION
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment50
Start date1 January 2023
Primary completion1 June 2025
Estimated completion1 June 2026
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

Chongqing University Cancer Hospital

Who can join

18 and older, female only, with Cervical Cancer Treated with Pelvic Radiotherapy or Cervical Cancers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a single-arm, single-center, open-label, Phase II study aimed at assessing the efficacy of organoids in predicting the response to radiotherapy and chemotherapy in cervical cancer

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Tumor Organoid and Microenvironment Cocultures: Implications for Basic and Translational Cancer Research.
    Yang J, Cheng C, Luo W, He X, et al · · 2026 · PMID 41987851 · DOI 10.1002/mco2.70741
  2. Recapitulating the tumour microenvironment: advancing personalised radiation therapy through organoid technology.
    Lan Z, Liu J, Li L, Yang Y, et al · · 2026 · PMID 41761263 · DOI 10.1186/s13046-026-03655-0
  3. Modeling Drug and Radiation Resistance with Patient-Derived Organoids: Recent Progress, Unmet Needs, and Future Directions for Lung Cancer.
    Lee D, Kim Y, Kang DH, Chung C. · · 2025 · PMID 41440014 · DOI 10.3390/cells14241994

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