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NCT06785987
Continuous Lidocaine Infusion in Thyroid Surgery Using Intraoperative Neurophysiological Monitoring
Phase 4 trial testing Continuous Lidocaine Infusion in Thyroid Disease in 100 participants. Enrolling by invitation.
31 March 2027
Quick facts
| Lead sponsor | Kaohsiung Veterans General Hospital. |
|---|---|
| Phase | Phase 4 |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 7 February 2024 |
| Primary completion | 31 March 2027 |
| Estimated completion | 31 March 2027 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Continuous Lidocaine Infusion — full drug profile →
- intermittent fentanyl infusion — full drug profile →
- Continuous remifentanil Infusion — full drug profile →
Conditions studied
- Thyroid Disease — all drugs for Thyroid Disease →
- Thyroid Surgery — all drugs for Thyroid Surgery →
- Lidocaine Infusion — all drugs for Lidocaine Infusion →
Sponsor
Kaohsiung Veterans General Hospital.
Who can join
Adults 20 to 75, any sex, with Thyroid Disease or Thyroid Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Thyroid surgery is a common procedure for the treatment of thyroid tumors, nodules and other related lesions. During this procedure, intraoperative neurophysiological monitoring is used to protect the recurrent laryngeal nerves. For the nerve monitor to work properly, a reduced muscle relaxant dosage is indicated. The main objectives of the anesthesiologist are maintaining deep sedation, analgesia and immobilization during surgery, as well as enhance post-operative recovery. Reduced muscle relaxant use during surgery poses the risk of inadequate immobilization during the operation, which may result in serious surgical complications. Intravenous bolus administration of fentanyl is currently the most popular method to maintain the depth of anesthesia during such operations. However, the side effects include intraoperative hypotension, bradycardia, and postoperative nausea and vomiting. The ultra-short acting remifentanil may be appropriate for inhibiting the bucking reflex during surgery, but the risk of opioid-induced hyperalgesia and opioid tolerance after surgery has been reported. In recent studies, intravenous lidocaine has been shown to increase the depth of anesthesia and provide analgesia, with no muscle relaxing effect. The aim of this study is to examine the depth of anesthesia, surgical operating conditions, and the recovery profile with the use of a continuous lidocaine infusion.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06785987 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kaohsiung Veterans General Hospital.
- Last refreshed: 1 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06785987.
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