Last reviewed · How we verify
NCT06775600
Stem Cell Isolation From Femoral Heads Post Total Hip Arthroplasty
NA trial testing Hip Replacement in Obesity and Type 2 Diabetes in 30 participants. Not yet recruiting.
1 May 2025
Quick facts
| Lead sponsor | David Hess |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 1 February 2025 |
| Primary completion | 1 May 2025 |
| Estimated completion | 1 August 2025 |
Drugs / interventions tested
- Hip Replacement
Conditions studied
- Obesity and Type 2 Diabetes — all drugs for Obesity and Type 2 Diabetes →
Sponsor
David Hess
Who can join
18 and older, any sex, with Obesity and Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Femoral heads will be collected at University Hospital (London, ON, Canada) from individuals with type-2 diabetes, obesity, and no T2D/no obesity controls. The femoral head will be taken to the Robarts Research Institute (London, ON, Canada) for lineage-restricted progenitor cell expansion and analyses. There the femoral heads will be used to isolate three stem cell types - Multipotent Stromal Cells, Endothelial Colony Forming Cells, and Hematopoietic Progenitor Cells. The yield and cell surface markers expressed on these cells will be measured using flow cytometry. These cell types will then undergo further analyses of the secretome, tubule forming assays, vascular regenerative cell exhaustion assays, and will be transplanted into immune deficient mice with with femoral artery ligation. These experiments are to assess the differences in function and expression of these cell types between individuals with type-2 diabetes and/or obesity and/or healthy controls.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06775600
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Hip Replacement
Trials testing the same drug.
- NCT04913623 — Correlation of Intramedullary Pressure and Systemic Inflammatory Parameters in Cemented Femoral Stem · unknown
Other recruiting trials for Obesity and Type 2 Diabetes
Currently open trials in the same condition.
- NCT06800794 — Investigating Metabolic and Psychological Adaptations in a Clinical Trial · NA · active not recruiting
- NCT07055516 — Evaluate the Efficacy and Safety of NT-0796 in Participants With Obesity With or Without Type 2 Diabetes Mellitus · Phase 2 · active not recruiting
- NCT06890169 — OneSTOP (One-Stop Telehealth Obesity Program) for Multidisciplinary Weight Management and Related Comorbidities · NA · recruiting
- NCT06943001 — Adapting and Assessing the Feasibility of a Telehealth Diabetes Prevention Program for Hispanic Adolescents · NA · recruiting
- NCT06830096 — Role of KATP Channel Loss in Type 2 Diabetes · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06775600 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by David Hess
- Last refreshed: 15 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06775600.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing