Last reviewed · How we verify
NCT06774651
Comparison of Femto LDV Z8 Corneal Lenticule Extraction for Advanced Refractive Correction (CLEAR) and Visumax Small Incision Lenticule Extraction (SMILE)
trial testing Procedure: Corneal lenticule extraction for advanced refractive correction (CLEAR) in Myopia in 65 participants. Currently enrolling.
31 October 2025
Quick facts
| Lead sponsor | Singapore Eye Research Institute |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 65 |
| Start date | 1 March 2023 |
| Primary completion | 31 October 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- Procedure: Corneal lenticule extraction for advanced refractive correction (CLEAR)
- Procedure: Small Incision Lenticule Extraction (SMILE)
Conditions studied
- Myopia — all drugs for Myopia →
Sponsor
Singapore Eye Research Institute
Who can join
Adults 21 to 50, any sex, with Myopia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This observational study aims to compare two laser corrective procedures for treating myopia and myopic astigmatism: a novel refractive technique, the CLEAR procedure, and the established SMILE procedure. Participants will be randomized to undergo CLEAR in one eye and SMILE in the other. The investigators will evaluate and compare the two procedures based on the following aspects: refractive predictability (how accurate the vision correction is) by measuring the proportion of eyes close to the target prescription after surgery, clinical dry eye outcomes, changes in tear proteins, and corneal nerve changes at 1, 3, 6, and 12 months after both surgeries. Metabolomic features of the removed corneal tissue and how precisely the laser is centered during surgery will also be examined. Our hypothesis is that CLEAR provides equally good vision results as SMILE, and explore any extra benefits of CLEAR.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE).
Yu M, Liu C, Lee IXY, Hsu VW, et al · · 2025 · cited 1× · PMID 40165267 · DOI 10.1186/s40662-025-00429-1
Verify or expand the search:
- PubMed search for NCT06774651
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Myopia
Currently open trials in the same condition.
- NCT07284966 — Comfort and Vision With TOTAL30 Multifocal Lenses · recruiting
- NCT07078799 — Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK Surgery · NA · recruiting
- NCT07585877 — Effect of Branched-Chain Amino Acid Supplementation on Myopia Progression · NA · active not recruiting
- NCT07354945 — An Evaluation of Myopia Control Lenses on Wearing Experience in Myopic Children · NA · recruiting
- NCT07229365 — Children's Viewing Behavior · NA · recruiting
Other Singapore Eye Research Institute trials
Trials by the same sponsor.
- NCT06983652 — Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal Edema · recruiting
- NCT06877988 — Artificial Intelligence (AI) - Assisted Visual Impairment Screening Model: Community-based Implementation and Evaluation · NA · active not recruiting
- NCT06967792 — Evaluation of the Safety of Terahertz Scanning System on Corneas · recruiting
- NCT07174739 — Efficacy of Quantum Molecular Resonance in Neuropathic Corneal Pain and Corneal Nerve Regeneration · NA · recruiting
- NCT05809674 — Polarization Sensitive Optical Coherence Tomography · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06774651 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Singapore Eye Research Institute
- Last refreshed: 14 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06774651.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing