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NCT06773351
A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane
Phase 4 trial testing Sevoflurane 0 + different doses of ciprofol in Induction of General Anesthesia in 300 participants. Not yet recruiting.
31 December 2025
Quick facts
| Lead sponsor | Feng Gao |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 1 February 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
Drugs / interventions tested
- Sevoflurane 0 + different doses of ciprofol — full drug profile →
- Sevoflurane 0.7% + different doses of ciprofol — full drug profile →
- Sevoflurane 1.0% + different doses of ciprofol 0.05
- Sevoflurane 1.5% + differnet doses of ciprofol — full drug profile →
- Sevoflurane 2.0% + different doses of ciprofol — full drug profile →
- Sevoflurane 2.5% + different doses of ciprofol — full drug profile →
- Ciprofol 0 + different end-expiratory concentration of sevoflurane
- Ciprofol 0.05mg/kg + different end-expiratory concentration of sevoflurane
- Ciprofol 0.1mg/kg + different end-expiratory concentration of sevoflurane
- Ciprofol 0.2 mg/kg + different end-expiratory concentration of sevoflurane
- Ciprofol 0.3 mg/kg + different end-expiratory concentration of sevoflurane
- Ciprofol 0.4 mg/kg + different end-expiratory concentration of sevoflurane
Conditions studied
- Induction of General Anesthesia — all drugs for Induction of General Anesthesia →
Sponsor
Feng Gao — full company profile →
Who can join
Adults 18 to 60, any sex, with Induction of General Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Intravenous and inhalation combined anesthesia is a commonly used method for maintaining general anesthesia in clinical practice. This study aims to explore the interaction between ciprofol and sevoflurane. By employing response surface methodology, we constructed a three-dimensional pharmacodynamic interaction surface for various dose combinations of ciprofol and sevoflurane. This approach allows us to determine the nature of the interaction between the two drugs at any given level, thereby providing a ciprofol understanding of the dose-response relationship when ciprofol and sevoflurane are used in combination. This knowledge will serve as a theoretical basis for rational drug administration during surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06773351
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06773351 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Feng Gao
- Last refreshed: 14 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06773351.
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