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NCT06763484: MENOXTINA
Paroxetine Versus Placebo for Vasomotor Symptom Management in Surgical Menopause
Phase 2 trial testing Paroxetine in Menopause Syndrome in 90 participants. Completed in 1 September 2025.
31 July 2025
Quick facts
| Lead sponsor | Universidad Nacional Autonoma de Honduras |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 30 January 2025 |
| Primary completion | 31 July 2025 |
| Estimated completion | 1 September 2025 |
| Sites | 1 location across Honduras |
Drugs / interventions tested
- Paroxetine — full drug profile →
- Placebo
Conditions studied
- Menopause Syndrome — all drugs for Menopause Syndrome →
- Menopause Surgical — all drugs for Menopause Surgical →
- Hot Flashes — all drugs for Hot Flashes →
Sponsor
Universidad Nacional Autonoma de Honduras — full company profile →
Who can join
Adults 18 to 80, female only, with Menopause Syndrome or Menopause Surgical. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
evaluate the efficacy of paroxetine in the management of vasomotor symptoms in patients with surgical menopause, in order to seek an alternative therapy to hormone therapy, which is associated with proinflammatory and procoagulant effects that increase the risk of thrombosis and is therefore contraindicated in people with diabetes mellitus, chronic arterial hypertension and patients with a history of thromboembolism
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06763484
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Paroxetine
Trials testing the same drug.
- NCT06232109 — Drug-Drug Interaction of ASN51 With Fluvoxamine, Itraconazole and Paroxetine in Healthy Subjects · Phase 1 · completed
- NCT06231745 — Paroxetine Safety and Efficacy in Rheumatoid Arthritis · Phase 3 · recruiting
- NCT06049797 — A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats · active not recruiting
- NCT06065735 — Concentration-QT Study of Paroxetine in Healthy Adults · Phase 1 · completed
- NCT05725837 — Effects of Paroxetine on Cardiovascular Function in Septic Patients · Phase 2 · recruiting
Other Universidad Nacional Autonoma de Honduras trials
Trials by the same sponsor.
- NCT07428317 — Use of Lubricant Gel to Shorten the Second Stage of Labor During Vaginal Delivery · NA · recruiting
- NCT07440069 — Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor · Phase 4 · recruiting
- NCT07411352 — Left Lateral Position vs Supine Position to Reduce Active Labor Duration · NA · recruiting
- NCT07401160 — Umbilical Cord Drainage to Prevent Postpartum Hemorrhage · NA · recruiting
- NCT07418151 — Effect of Maternal Chocolate Consumption on Fetal Non-Stress Test (NST) Reactivity. · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06763484 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad Nacional Autonoma de Honduras
- Last refreshed: 17 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06763484.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing