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NCT06761469: LAST•Br
Leprosy Active Searching Trial in Brazil
NA trial testing Implementing active-case finding strategies in Leprosy in 1,925 participants. Currently enrolling.
31 March 2026
Quick facts
| Lead sponsor | Hospital Alemão Oswaldo Cruz |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | screening |
| Enrollment | 1,925 |
| Start date | 1 June 2025 |
| Primary completion | 31 March 2026 |
| Estimated completion | 31 May 2026 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Implementing active-case finding strategies
Conditions studied
- Leprosy — all drugs for Leprosy →
Sponsor
Hospital Alemão Oswaldo Cruz
Who can join
Eligibility, any sex, with Leprosy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices. The main questions it aims to answer are: \- Does the intervention increase the number of new leprosy cases detected compared to standard care? Participants will: * Receive community awareness about leprosy. * Be screened using the Leprosy Suspicion Questionnaire at priority areas identified by georeference tools. * Undergo clinical evaluation by a trained medical team. * If leprosy is diagnosed, affected patients will collect complementary laboratory exams Healthcare professionals from primary care units will receive training in leprosy, while researchers will monitor changes in leprosy incidence over a 12-month period using data from Brazil's national notification system. The study will provide insights into underdiagnosis and the clinical profiles of patients who have been diagnosed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06761469
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Leprosy
Currently open trials in the same condition.
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- NCT06683690 — TGF β 1 Expression Related Gene Polymorphism · recruiting
- NCT05597280 — Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy · Phase 3 · recruiting
- NCT05243654 — Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy · Phase 2 · recruiting
Other Hospital Alemão Oswaldo Cruz trials
Trials by the same sponsor.
- NCT07096960 — Implementation of the START Intervention in Brazil: a Controlled Feasibility Trial · NA · recruiting
- NCT07514884 — Antimicrobial Stewardship Program Implementation in Brazilian Public Hospitals (PeGASUS) · NA · active not recruiting
- NCT05515653 — Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population · active not recruiting
- NCT04757857 — COVID-19 Antithrombotic Rivaroxaban Evaluation · Phase 4 · terminated
- NCT04466540 — Randomized Placebo-controlled Trial of Hydroxychloroquine in Outpatient Cases With Coronavirus Disease 2019 (COVID-19) · Phase 4 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06761469 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Alemão Oswaldo Cruz
- Last refreshed: 2 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06761469.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing