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NCT06758492: NEU-VODEtec
A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants
trial testing Video laryngoscopy used to insert thin endotracheal catheter in Respiratory Distress Syndrome (Neonatal) in 600 participants. Currently enrolling.
13 December 2025
Quick facts
| Lead sponsor | University College Dublin |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 600 |
| Start date | 13 January 2025 |
| Primary completion | 13 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 16 locations across Italy, Greece, Hungary, Norway, Poland, Romania, Croatia, Spain |
Drugs / interventions tested
- Video laryngoscopy used to insert thin endotracheal catheter
- Direct laryngoscopy used to insert thin endotracheal catheter
Conditions studied
- Respiratory Distress Syndrome (Neonatal) — all drugs for Respiratory Distress Syndrome (Neonatal) →
- Respiratory Distress Syndrome (RDS) — all drugs for Respiratory Distress Syndrome (RDS) →
- Video Laryngoscopy — all drugs for Video Laryngoscopy →
- Surfactant — all drugs for Surfactant →
Sponsor
University College Dublin
Who can join
Adults 0 Minutes to 28 Days, any sex, with Respiratory Distress Syndrome (Neonatal) or Respiratory Distress Syndrome (RDS). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Many premature babies have breathing difficulty after birth and receive help with a breathing machine (nasal continuous positive airway pressure, NCPAP). Some of the babies whose breathing gets worse despite NCPAP are treated with surfactant, a medication that is given directly into their windpipe (trachea). Some of the babies who are given surfactant get it through a ventilation tube (endotracheal tube, ETT), while others get it through a thin catheter that is too small for ventilation. When doctors insert a tube or a thin catheter into the windpipe of a baby, they use an instrument called a laryngoscope, which has a light at its tip, to identify the entrance. Most often doctors look directly into the baby's mouth with a standard laryngoscope to identify the entrance to the windpipe. However, newer video laryngoscopes have a camera along with the light at their tip, which displays a picture of the entrance to the windpipe on a screen. In a study performed at one hospital, doctors inserted an ETT first time more often when they used a video laryngoscope. The investigators are doing a study at many hospitals where doctors usually use a standard laryngoscope to insert tubes and thin catheters into a baby's trachea by looking directly into the mouth. Each hospital will switch one-by-one to using a video laryngoscope when inserting a tube. The investigators will compare the information we collect to see if more babies who have a tube inserted first time without falls in their oxygen levels or heart rate with a video laryngoscope. The investigators will also collect information on babies who have a thin catheter inserted to compare whether doctors use fewer attempts when they use a video laryngoscope.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06758492
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other recruiting trials for Respiratory Distress Syndrome (Neonatal)
Currently open trials in the same condition.
- NCT07237139 — Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation · recruiting
- NCT05960929 — InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS · Phase 3 · recruiting
Other University College Dublin trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06758492 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College Dublin
- Last refreshed: 20 February 2025
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing