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NCT06752395
Cryobiopsy Vs. Forceps Biopsy for Peripheral Pulmonary Lesions
NA trial testing Transbronchial lung biopsy with radial probe endobronchial ultrasound (Cryobiopsy centered) in Lung Cancer (NSCLC) in 200 participants. Enrolling by invitation.
1 November 2025
Quick facts
| Lead sponsor | Pusan National University Hospital |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 200 |
| Start date | 1 November 2024 |
| Primary completion | 1 November 2025 |
| Estimated completion | 1 November 2026 |
| Sites | 3 locations across South Korea |
Drugs / interventions tested
- Transbronchial lung biopsy with radial probe endobronchial ultrasound (Cryobiopsy centered)
- Transbronchial lung biopsy with radial probe endobronchial ultrasound (Forceps biopsy centered)
Conditions studied
- Lung Cancer (NSCLC) — all drugs for Lung Cancer (NSCLC) →
Sponsor
Pusan National University Hospital
Who can join
18 and older, any sex, with Lung Cancer (NSCLC). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This multicenter clinical trial evaluates the diagnostic yields of cryobiopsy and forceps biopsy for peripheral lung nodules. In the cryobiopsy group, cryobiopsy is the primary method, supplemented by forceps biopsy. Conversely, in the forceps biopsy group, forceps biopsy is the primary method, supplemented by cryobiopsy. The study also explores the complementary relationship between the two methods and examines differences in diagnostic rates based on the order in which the procedures are performed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cryobiopsy-Based Tri-Modality Sampling Using an Ultrathin Bronchoscope for the Diagnosis of Peripheral Lung Lesions: A Prospective Observational Study.
Seong H, Kim SH, Mok J, Kim MH, et al · · 2025 · PMID 40451176 · DOI 10.1159/000546433
Verify or expand the search:
- PubMed search for NCT06752395
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06752395 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pusan National University Hospital
- Last refreshed: 3 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06752395.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing