Last reviewed · How we verify
NCT06746623
Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
NA trial testing Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy. in Obese Patients in 400 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | Louis Stokes VA Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 400 |
| Start date | 11 April 2025 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy.
Conditions studied
- Obese Patients — all drugs for Obese Patients →
- Tobacco Use — all drugs for Tobacco Use →
- Veterans — all drugs for Veterans →
- Family History of Esophageal Cancer — all drugs for Family History of Esophageal Cancer →
Sponsor
Louis Stokes VA Medical Center
Who can join
Adults 40 to 85, any sex, with Obese Patients or Tobacco Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population. BE is traditionally diagnosed only when patients undergo endoscopy with biopsies. However, due to the high cost of endoscopy and the lack of studies proving efficacy of screening, endoscopy to screen for BE is not routinely recommended. A simpler screening procedure similar to a pap smear would be an ideal way to sample the esophageal tissue for cancer and its precursor condition, BE. This study proposes a non-endoscopic detection method administered in outpatient offices which would increase subsequent endoscopic detection of BE. The study team will be enrolling veterans who do not have history of gastroesophageal reflux but have multiple risk factors for esophageal adenocarcinoma.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06746623
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Obese Patients
Currently open trials in the same condition.
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- NCT06929000 — A Study on Application of Adjustable Headrest in Painless Curettage Surgery for Overweight and Obese Patients · NA · recruiting
- NCT06590584 — Validity and Reliability of the 6-minute Pegboard Ring Test in Obese Individuals · recruiting
- NCT07070908 — Modifications to Gastric Sleeve: Implications for GRED and Quality of Life · NA · active not recruiting
Other Louis Stokes VA Medical Center trials
Trials by the same sponsor.
- NCT05210049 — Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans · NA · unknown
- NCT04855214 — Evaluating the Experience of Upper Limb Prosthesis Use · recruiting
- NCT04935892 — Slippers to Reduce Transfer From Floors to Surfaces · NA · completed
- NCT06969846 — Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects · NA · completed
- NCT03409133 — Feasibility of Neural Feedback for Lower Limb Amputees · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06746623 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Louis Stokes VA Medical Center
- Last refreshed: 5 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06746623.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing