Last reviewed · How we verify
NCT06746597
Evaluating Skin Changes Using Optical Coherence Tomography on Plantar Layers
NA trial testing Walking intervention on plantar skin thickness and stiffness in Skin Thickness in 20 participants. Participants enrolled and being followed up; not accepting new ones.
22 December 2025
Quick facts
| Lead sponsor | Asia University |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 20 |
| Start date | 23 January 2024 |
| Primary completion | 22 December 2025 |
| Estimated completion | 22 December 2025 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Walking intervention on plantar skin thickness and stiffness
Conditions studied
- Skin Thickness — all drugs for Skin Thickness →
- Skin Stiffness — all drugs for Skin Stiffness →
Sponsor
Asia University
Who can join
Adults 18 to 60, any sex, with Skin Thickness or Skin Stiffness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn if there are changes in plantar skin surface walking intervention in different air-insole pressures and durations. The main questions it aims to answer are: How far does walking intervention affect the changes in epidermis layers? What conditions affect the most in the plantar surface, the different air-insole pressures or the different durations? Researchers will compare the use of three different air-insole pressures (80 mmHg, 160 mmHg, and 240 mmHg) in two different durations (10 and 20 minutes) to see how far the plantar skin surface changes in thickness and stiffness. Participants will: Get their plantar region checked and measured by Optical coherence tomography in thickness and stiffness before the walking intervention. Walk with a custom-made shoe using adjusted air-insole pressures (80 mmHg, 160 mmHg, and 240 mmHg) in two different durations (10 and 20 minutes) Get their plantar region checked and measured by Optical coherence tomography in thickness and stiffness after the walking intervention.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Investigating plantar soft tissue elasticity modulation using air insoles during walking.
Prisilla AA, Haris F, Jan YK, Liau BY, et al · · 2026 · PMID 41507900 · DOI 10.1186/s12891-025-09427-9
Verify or expand the search:
- PubMed search for NCT06746597
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Skin Thickness
Currently open trials in the same condition.
- NCT04540900 — A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) fo · Phase 1 · active not recruiting
Other Asia University trials
Trials by the same sponsor.
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- NCT06527716 — Digital Multimedia in Clinical Nurse Education for Pressure Injury Prevention Via LINE@ · NA · not yet recruiting
- NCT07177274 — Evaluation of Skin Stiffness Changes in Wounds Before and After Low-Level Laser Therapy · NA · active not recruiting
- NCT07366073 — Effects of Virtual Reality Dementia Education on College Students' Knowledge and Attitudes · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06746597 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Asia University
- Last refreshed: 10 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06746597.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing