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NCT06746389: VIPER
Effects of Vitamin D Supplementation on Muscle Protein Synthesis
Phase 2 trial testing 3000 IU per Day Spray in Vitamin D Effects on MPS in 18 participants. Completed in 23 October 2024.
23 June 2024
Quick facts
| Lead sponsor | University of Exeter |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 18 |
| Start date | 8 October 2020 |
| Primary completion | 23 June 2024 |
| Estimated completion | 23 October 2024 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- 3000 IU per Day Spray
Conditions studied
- Vitamin D Effects on MPS — all drugs for Vitamin D Effects on MPS →
- Placebo Effects on MPS — all drugs for Placebo Effects on MPS →
Sponsor
University of Exeter
Who can join
Adults 18 to 45, any sex, with Vitamin D Effects on MPS or Placebo Effects on MPS. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Healthy adults maintain muscle tissue by continuously building up and breaking down muscle proteins throughout the day. Studies have shown that vitamin D (VitD) is essential for maintaining muscle mass by activating cellular pathways involved in building muscle via muscle protein synthesis (MPS). Although, various candidate molecules have been identified in animal models, it is not known whether these pathways are activated in humans. Interestingly, animal studies indicate that 20% of VitD is stored in human muscle cells, which may help maintain VitD sufficiency during winter in Northern latitudes when there is not much sunlight Objectives: We will investigate whether VitD supplementation increases the MPS response to feeding and exercise, VitD storage in muscle cells, and cellular pathways that are involved in healthy sedentary or moderately active adults. Methods: Participants will consume either a placebo (sucrose) or the intervention (vitamin D3, 3000IU/day) for 12 weeks in a double-blinded randomised study. Before and after the intervention participants will have body composition measured. Blood and muscle samples will be taken before and after a bout of exercise and ingestion of 20 g protein in order to measure MPS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06746389 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Exeter
- Last refreshed: 24 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06746389.
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