Last reviewed · How we verify
NCT06740656
Neuromuscular Complications of MEK Inhibitors: a French Case Series and a Systematic Review of the Literature
trial testing No Interventions in Myositis in 5 participants. Not yet recruiting.
1 January 2026
Quick facts
| Lead sponsor | Central Hospital, Nancy, France |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 5 |
| Start date | 1 March 2025 |
| Primary completion | 1 January 2026 |
| Estimated completion | 1 January 2026 |
| Sites | 1 location across France |
Drugs / interventions tested
- No Interventions — full drug profile →
Conditions studied
- Myositis — all drugs for Myositis →
- Myasthaenia Gravis — all drugs for Myasthaenia Gravis →
- Neuropathy — all drugs for Neuropathy →
- Guillain Barré Syndrome — all drugs for Guillain Barré Syndrome →
Sponsor
Central Hospital, Nancy, France
Who can join
18 and older, any sex, with Myositis or Myasthaenia Gravis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
MEK inhibitors (trametinib, cobimetinib, selumetinib or binimetinib) have been used since 2016 to treat metastatic melanoma, by targeting the MAPK pathway Neuromuscular complications (neuropathy, myasthenia or myositis) have been reported in patients treated with MEK inhibitors. With the growing use of these new oncology therapies, neurologists, oncologists and other clinicians are likely to be increasingly confronted with MEK inhibitor-induced neuropathy, myasthenia or myositis. Yet, so far, these complications have only been documented in a few single case reports. Our aim was to characterize the neuromuscular complications associated with MEK inhibitors used either alone or in combination.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06740656
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of No Interventions
Trials testing the same drug.
- NCT07473284 — Incidence and Characteristic of CRT Persistent After Catheter Extraction in ICU Patients · not yet recruiting
- NCT07413380 — Effects of Arm Measurements on Upper Limb Skills and Reaction Time · NA · not yet recruiting
- NCT07536711 — Ego-Tucking: Exploring the Psychological Mechanisms of the "Fo-xi" Phenomenon Among University Students · completed
- NCT07409376 — Comparison of the Therapeutic Effects of Balloon Assisted Enteroscopy Assisted Narrow Incision and Balloon Dilation in t · NA · not yet recruiting
- NCT07356115 — Association of High PainDETECT Scores With Pain Region and Diagnosis in Patients Attending a Musculoskeletal and Sports · recruiting
Other recruiting trials for Myositis
Currently open trials in the same condition.
- NCT06925542 — A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease · Phase 1 · recruiting
- NCT06587724 — Investigation of the Validity, Reliability, and Responsiveness of the BETY-BQ in Myositis · recruiting
- NCT05895786 — A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathie · Phase 3 · recruiting
- NCT05523167 — A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Infl · Phase 2, PHASE3 · active not recruiting
- NCT05379634 — A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies · Phase 2 · active not recruiting
Other Central Hospital, Nancy, France trials
Trials by the same sponsor.
- NCT06452290 — PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder · NA · not yet recruiting
- NCT07518498 — Hypnosis During Mechanical Ventilation Weaning · NA · not yet recruiting
- NCT07471334 — Prospective Study of Postictal Psychotic Symptoms Occuring After Video-EEG Monitoring in Focal Epilepsies · NA · not yet recruiting
- NCT07414667 — Primary Sjögren's Syndrome: Impact of Quantitative Anti-Ro52 Antibody Analysis on Patient Prognosis and Stratification ( · not yet recruiting
- NCT07415759 — Imaging of Electrical Properties by MRI: Investigation of Age-Related Changes · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06740656 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Central Hospital, Nancy, France
- Last refreshed: 18 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06740656.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing