Last reviewed · How we verify
NCT06740331: COMET
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
NA trial testing Analysis of social cognition, memory functioning, and executive functioning processes in Bipolar Disorder and Major Depressive Disorder in 180 participants. Currently enrolling.
7 January 2028
Quick facts
| Lead sponsor | CHU de Reims |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 180 |
| Start date | 7 January 2025 |
| Primary completion | 7 January 2028 |
| Estimated completion | 7 February 2028 |
| Sites | 1 location across France |
Drugs / interventions tested
- Analysis of social cognition, memory functioning, and executive functioning processes
Conditions studied
- Bipolar Disorder and Major Depressive Disorder — all drugs for Bipolar Disorder and Major Depressive Disorder →
Sponsor
CHU de Reims — full company profile →
Who can join
Adults 18 to 65, any sex, with Bipolar Disorder and Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their social functioning and quality of life. This study aims to explore social cognition deficits (e.g., emotional processing, theory of mind, attribution bias) and their relationship with executive functions (e.g., flexibility, inhibition, working memory) and memory in bipolar disorder and major depressive disorder, ultimately seeking to improve understanding of their functional outcomes. Social cognition and executive functions in BD are both state- and trait-related. One recent meta-analysis demonstrated impairment in social cognitive domains for manic, depressive, and euthymic bipolar disorders' patients but it remains unclear whether these social cognitive deficits in BD are due to executive functions and/or other confounding effects. Few studies have investigated the interdependency between these cognitive impairments in these two affective disorders while a better understanding of the link between executive functions and social cognition seems crucial in order to better characterize the nature of patients' deficits and thus their caring.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06740331
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06740331 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CHU de Reims
- Last refreshed: 13 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06740331.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing