NCT06732414

A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up

Recruiting now Last updated 2 December 2025

What this trial tests

trial in Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a in 10,000 participants. Currently enrolling.

Timeline

28 January 2025

Primary endpoint
1 November 2044

1 November 2045

Quick facts

Lead sponsor	National Institute of Allergy and Infectious Diseases (NIAID)
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	10,000
Start date	28 January 2025
Primary completion	1 November 2044
Estimated completion	1 November 2045
Sites	1 location across United States

Conditions studied

• Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a — all drugs for Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a →

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Who can join

Adults 3 to 100, any sex, with Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

Allergic or sinus diseases can affect the skin, sinuses, airways, and other parts of the body. Examples include pollen and environmental allergies, food allergies, asthma, and eczema. To learn more about how to prevent and treat these diseases, researchers need to study data, blood, fluid, and tissue samples from people affected by them.

Objective:

To collect data, blood, fluid, and tissue samples from people with allergic or sinus diseases.

Eligibility:

People aged 3 to 100 years with allergic or sinus diseases.

Design:

Participants will have at least one clinic visit, and most participants will have a baseline visit, annual visit, and an end of study visit. The duration of the study is 1 to 3 years. During the first clinic visit, the following procedures will be done to collect data, blood, fluid, and tissue samples:

* Blood will be collected.
* Cells and fluid may be collected from the inside of the nose using a long swab, and a small piece of skin may be scraped from inside the nose.
* Skin cells will be collected by rubbing with a cotton swab.
* A urine sample will be collected.
* Allergy skin prick tests. Allergy-causing substances will be placed on the back or arm and the skin underneath gently scratched. If the participant is allergic to the substance, the skin may become red, itchy, and swollen locally ( at the site of the test).
* Lung function test. Participants will breathe into a machine that measures the air moving in and out of their lungs.
* If, as part of their routine care, participants are undergoing procedures such as having nasal polyps removed, skin tissue samples taken, or gastrointestinal biopsies, additional tissues may be collected for this study.
* Participants will complete online questionnaires regarding their symptoms, health, and life.

Participants may return for more visits for up to 3 years.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.