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NCT06728696
Peri-implant Tissue Changes Using Dual Zone Concept with Connective Tissue Graft Versus Concentrated Growth Factor
NA trial testing Immediate implant with with dual zone technique using concentrated growth factor graft. in Hopeless Tooth in Esthetic Zone in 34 participants. Enrolling by invitation.
15 March 2025
Quick facts
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 34 |
| Start date | 15 January 2025 |
| Primary completion | 15 March 2025 |
| Estimated completion | 15 June 2025 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Immediate implant with with dual zone technique using concentrated growth factor graft.
- Immediate implant with dual zone technique using connective tissue graft.
Conditions studied
- Hopeless Tooth in Esthetic Zone — all drugs for Hopeless Tooth in Esthetic Zone →
- Loss of Soft and Hard Tissue Around Implant — all drugs for Loss of Soft and Hard Tissue Around Implant →
- Immediate Implant Placement — all drugs for Immediate Implant Placement →
Sponsor
Ain Shams University
Who can join
Adults 20 to 50, any sex, with Hopeless Tooth in Esthetic Zone or Loss of Soft and Hard Tissue Around Implant. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Tooth extraction not only alters the bony architecture of the alveolar ridge, but it also has an impact on the surrounding soft tissues. Post-extraction recovery of both hard and soft tissues occurs uneventfully, resulting in horizontal and vertical tissue loss, affecting prosthetic rehabilitation with dental implants or tooth-supported prosthesis. Aim of the study: The aim of this study is to evaluate volumetric soft tissue alterations as well as clinical, radiographic, and esthetic outcomes in dual zone technique (DZ) using CTG (Connective Tissue Graft) versus CGF (Concentrated Growth Factor) Graft following maxillary IIP (Immediate Implant Placement) in the esthetic zone. Materials and methods: 20 patients with hopeless teeth requiring extraction in maxillary esthetic zone and requiring replacement with dental implants, will be enrolled and recruited from the outpatient clinic, faculty of dentistry, Ain Shams University according to the inclusion criteria. They will be randomly allocated into two equal groups. Group I (n=17) immediate implant placement with dual zone technique using concentrated growth factor graft and group II (n=17) immediate implant placement with dual zone technique using connective tissue graft. Pink esthetic score (PES) was measured 6 months after the final crown placement. At the respective times radiographic CBCT measurements, volumetric analysis, and clinical measurements will be taken. Postoperative medication will be prescribed to the patient and postoperative instructions will be explained in detail. Follow-up will be performed. Data collected will be tabulated and statistically analyzed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06728696
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06728696 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
- Last refreshed: 17 February 2025
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