NCT06723860: CCRP

The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Survivors

Not yet recruiting Last updated 9 December 2024

What this trial tests

trial in Post Intensive Care Syndrome (PICS) in 3,000 participants. Not yet recruiting.

Timeline

30 January 2025

Primary endpoint
30 December 2026

30 December 2027

Quick facts

Lead sponsor	University of British Columbia
Status	Not yet recruiting
Study type	OBSERVATIONAL
Enrollment	3,000
Start date	30 January 2025
Primary completion	30 December 2026
Estimated completion	30 December 2027

Conditions studied

• Post Intensive Care Syndrome (PICS) — all drugs for Post Intensive Care Syndrome (PICS) →
• Polypharmacy — all drugs for Polypharmacy →
• Adverse Drug Events — all drugs for Adverse Drug Events →
• Critical Care, Intensive Care — all drugs for Critical Care, Intensive Care →

Sponsor

University of British Columbia

Who can join

18 and older, any sex, with Post Intensive Care Syndrome (PICS) or Polypharmacy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background and Objective: Intensive Care Units (ICUs) save lives, but many ICU survivors face ongoing health issues, including adverse drug events (ADEs) from medications started during their hospital stay. These ADEs lead to emergency department visits and hospital admissions. Our project aims to improve the health of ICU survivors by creating a clinic that focuses on managing post-ICU health. The clinic will track and address medical issues that arise after ICU discharge and focus on deprescribing, or safely stopping, medications that may no longer be needed or could be harmful.

Project Plan: The clinic will be set up within the CARES clinic at VGH. Patients will be enrolled when they leave the ICU and will have follow up visits after hospital discharge. During these visits, the team will review each patient's medications and develop a personalized plan to reduce or stop unnecessary medications. We will also monitor patients for any new health issues that arise and provide eduction to patients and caregivers about managing their health.

Research and Evaluation: We will collect and analyze data on patient health outcomes, including the incidence of ADEs, hospital reeadmissions, and emergency department visits. We hope to show that patients who receive follow up care have better health outcomes and use fewer healthcare resources than a historical cohort. This data will help us demonstrate the cost-effectiveness of the clinic and support the need for expanding ICU follow up programs in British Columbia.

Long-term goals: We plan to establish a post-ICU care working group and expand the clinic model to other hospitals. Over the long term, we hope to standardize post-ICU care across BC, ensuring that all ICU survivors have access to comprehensive follow up care. This project will also lay the groundwork for future research on deprescribing medications for ICU related complications, which tend to improve or resolve once critical illness has resolved. The CCRP clinic will provide a setting to conduct clinical deprescription trials to establish whether long-term treatment of these complications is necessary.

Conclusion: Establishing a post-ICU discharge follow up clinic with a focus on deprescription has the potential to improve the long-term health and quality of life for ICU survivors. By reducing unnecessary medications, we can prevent complications, reduce hospital readmissions and demonstrate the value of comprehensive post-ICU follow up care.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.