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NCT06720415
Oral and Intravenous Methadone for Analgesia in Cardiac Surgery
Phase 4 trial testing Oral methadone, immediately prior to transport in Anesthesia in 41 participants. Completed in 14 July 2025.
7 July 2025
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 41 |
| Start date | 14 April 2025 |
| Primary completion | 7 July 2025 |
| Estimated completion | 14 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Oral methadone, immediately prior to transport — full drug profile →
- Intravenous methadone — full drug profile →
Conditions studied
- Anesthesia — all drugs for Anesthesia →
- Cardiac Surgery — all drugs for Cardiac Surgery →
Sponsor
Mayo Clinic
Who can join
18 and older, any sex, with Anesthesia or Cardiac Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06720415
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06720415 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 14 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06720415.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing